D-半乳糖对小鼠脾淋巴细胞功能的影响  

The Effect of D-Galactose on Splenolymphocytes and its Function of Mice

作　　者：冯明功[1] 李建 刘玉凤[3] 

机构地区：[1]大连大学医学院,辽宁大连116622 [2]大连市结核病医院,辽宁大连116622 [3]吉林安图县医院,吉林安图133600

出　　处：《大连大学学报》2000年第2期80-82,共3页Journal of Dalian University

摘　　要：目的：探讨Ｄ－半乳糖（Ｄ－Ｇａｌ）对小鼠脾淋巴细胞损伤的分子机理．方法：测定不同浓度Ｄ－Ｇａｌ作用后小鼠淋巴细胞乳酸脱氢酶（ＬＤＨ）、超氧化物歧化酶 （ＳＯＤ）、琥珀酸脱氢酶（ＳＤＨ）活性以及过氧化脂质（ＬＰＯ）水平．结果：与对照组比较，ＬＤＨ、ＳＯＤ和ＳＤ Ｈ活性均有显著降低（Ｐ＜０．０１），ＬＰＯ水平显著提高（Ｐ＜０．０１）．结论：Ｄ－Ｇａｌ能引起小鼠脾淋巴细胞及其功能的损伤．Object To discuss the molecule mechanism of damage on mouse splenolymphocytes by D -galactose(D-Gal). Method The mouse spleen cells were cultivated with different density of D-Gal in vitro. Results As Compared with the control group, Lactate dehydrogenase (LDH) activity. Superoxide Dismutase (SOD) activity and Succinate dehydrogenase(SDH) of D -Gal group decreased distinctly, however, Lipid Peroxyl (LPO) increased distinctly. Conclusion D -Gal can cause peroxidate damage of mouse spleen lymphocyte and its function.

关 键 词：D-半乳糖 脾淋巴细胞 乳酸脱氢酶 超氧化物歧化酶 琥珀酸脱氢酶 

分 类 号：R331.144[医药卫生—人体生理学]