rhEPO和睾酮对低氧小鼠血清ASTase、ALTase、LDHase活性抑制效应  

Inhibitory Effects of rhEPO and Testosterone on Serum ASTase, ALTase, LDHase Activity in Mice with Hypoxia

作　　者：孟庆瑜[1] 孟宪法[1] 姜如冈[2] 

机构地区：[1]大连大学医学院,辽宁大连116622 [2]天津医科大学,天津300070

出　　处：《大连大学学报》2000年第4期82-84,87,共4页Journal of Dalian University

基　　金：辽宁省教委高等学校科学研究项目!(9649311284)

摘　　要：目的观察ｒｈＥＰＯ和睾酮对低氧小鼠血清ＡＳＴａｓｅ、ＡＬＴａｓｅ、ＬＤＨａｓｅ活性的影响．方法应用低压舱小鼠实验（０．４２ａｔｍ，２２ｈ／ｄ， ６ｄａｙｓ），分别注射ｒｈＥＰＯ（２００ｕ／ｋｇ·ｄ）、宰酮（２．５ ｍｇ／ｄ）、皮质醇（０．５ ｍｇ／ｄ），检测血清酶活性、血清 ＥＰＯ浓度和 Ｈｃｔ．结果ｒｈＥＰＯ和睾酮不同程度地抑制低氧小鼠血清酶活性．结论ｒｈＥＰＯ和睾酮对低氧动物肝功能具有不同程度地保护效应。Objective: To explore the effects of rhEPO and testosterone on serum ASTase, ALTase, LDHase enzyme activity in mice with hypoxia. Methods: The experimental model of mice was established to be exposed to hypobaric chamber(0.42atm, 22h/d) over a 6 days period, injected by rhEPO (200u/kg· d), testosterone (2.5mg/d) cortisol (0.5mg/d) respectively and examined serum enzyme activity, serum EPO and hematocrit. Results: The inhibitory effects of rhEPO and testosterone on serum enzyme activity were occurred in mice with hypoxia stress continuously. Conclusions: The protective effect on liver function by administered rhEPO or testosterone in mice with hypoxia.

关 键 词：RHEPO 睾酮 促红细胞生成素 高原红细胞增多症 血清 活性抑制效应 肝功能 

分 类 号：R594.3[医药卫生—内科学] R333.4[医药卫生—临床医学]