新缩瞳药包公藤甲素类似物的研究  

Studies on Analogs of Baogongteng A——A New Myotic Agent

作　　者：王丽平[1] 姚天荣[1] 

机构地区：[1]上海第二医科大学

出　　处：《上海化工》1992年第4期24-27,共4页Shanghai Chemical Industry

摘　　要：本文以6β-羟基-3-托品酮和6β-乙酰氧基-3α-托品醇为原料,合成7个包公藤甲素类似物。经药理筛选其中两个,即对甲基苯甲酸一6β-乙酰氧基-3α-托品酯和3α,6β-二乙酰氧基托品烷具有纵肠肌收缩作用。Seven Baogongteng A analogs were synthesized from 6β-hydroxy-3-tropanone and 6β-acetoxy -3α-tropahol, and preliminary pharmacological results showed that p-methyl benzoic acid-6β-acetoxy-3α -tropanoate and 3α, 6β-diacetoxy-tropane in this series possess longitudinal muscle of guinea pig ileum contrac- tion.

关 键 词：缩瞳药 包公藤甲素 羟基托器酮 

分 类 号：R988.7[医药卫生—药品]