糖尿病患者肌肉和脂肪组织含量与其骨密度的关系  

Body composition and bone density in patients with diabetes mellitus

作　　者：冯波[1] 倪亚芳[1] 孙勤[1] 张冬梅[1] 李惠芝[1] 李栩[1] 王蔚薇[1] 

机构地区：[1]同济大学附属东方医院内分泌科,上海200120

出　　处：《中华物理医学与康复杂志》2002年第7期414-416,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　探讨糖尿病患者肌肉组织和脂肪组织含量与髋骨骨折危险性的关系。方法　采用双能X线分析仪 (DEXA)测定 76例 2型糖尿病患者全身各部位的骨密度和肌肉、脂肪含量 ,并根据股骨颈骨密度将患者分为骨质疏松组 (17例 )与非骨质疏松组 (5 9例 )。结果　骨质疏松组各部位骨密度和脂肪含量显著降低 (P <0 .0 5～ 0 .0 1) ,腿部和躯干肌肉含量显著降低 (P <0 .0 5～ 0 .0 1)。股骨颈骨密度与腿部肌肉含量呈显著正相关 (P <0 .0 1) ,而与脂肪含量无显著相关。结论　高肌肉组织和脂肪组织含量可降低糖尿病患者髋骨骨折的危险性。Objective To evaluate the relationship of lean body mass and fat mass with the risk of hip fracture in patients with diabetes mellitus. Methods Seventysix type 2 diabetics with mean age of 63.8 years, mean duration of disease of 6.9 years, mean HbA 1c of 9.2% were involved in the study, and their bone mineral density (BMD), lean body mass, total and regional fat mass of the body were determined by using the technique of dual energy Xray absorptiometry (DEXA). These patients were then divided into two groups according to the determined BMD of femur neck: Group 1 with osteoporosis ( n =17) and group 2 without osteoporosis ( n =59). Results There were markedly reduced BMD and fat mass in total and regional part of the body in group 1 compared with those in group 2 ( P <0.05～0.01). Significant reductions in lean mass of leg and trunk were also found in group 1 ( P <0.05～0.01). BMD of the femur neck was correlated significantly and positively with the lean body mass of legs ( P <0.01), but not with their fat mass ( P >0.05). Conclusion High lean mass and fat mass may reduce the risk of hip fracture in patients with diabetes mellitus.

关 键 词：糖尿病 肌肉 脂肪组织 含量 骨密度 

分 类 号：R587.1[医药卫生—内分泌]