饮水微量元素与老年人群认知能力关系研究  

Relations between trace elements in drinking water and elderly residents'cognitive function

作　　者：梁超轲[1] 吉荣娣[1] 曹静祥[1] 姜玉亭 余波 马凤[1] 吴云鹏[1] 应波[1] 张妍[1] 孙淑庄[1] Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京,100050 [2]山东省高密市卫生防疫站 [3]河南省地方病防治研究所 [4]美国罗玛林达大学牙科学院 [5]美国印第安纳大学医学院

出　　处：《卫生研究》2003年第5期436-440,共5页Journal of Hygiene Research

基　　金：美国NIH (P30AG1 0 1 33)和EliLilly基金资助

摘　　要：在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。The relationship between trace element levels in drinking water and cognitive function was studied for elderly residents in rural areas in China. Cognitive function was measured by a Chinese translation of the Community Screening Interview for Dementia (CSI“D'). The trace elements fluoride, calcium, selenium, aluminum, iron, zinc, cadmium, lead and arsenic contents of drinking water were determined using Chinese National Standard Methods. A mixed effects model was used to evaluate the effect of each of the elements on cognitive function while adjusting for age, sex, and education level. Several of the elements examined had a significant effect on cognitive function when they were examined in a univariate context. However, after adjusting for other elements many of these results were not significant. There was a significant quadratic effect for calcium and a significant zinc-cadmium interaction. Cognitive function increased with calcium level to a certain point, and then decreased as calcium continued to increase. Zinc showed a positive relationship with cognitive function at low cadmium levels, but a negative relationship at high cadmium levels.

关 键 词：饮水 微量元素 老年人群 认知能力 老年性痴呆症 

分 类 号：R123.1[医药卫生—环境卫生学] R749.16[医药卫生—公共卫生与预防医学]