铁对链脲佐菌素糖尿病大鼠过氧化和非酶糖化作用的影响  

Effect of iron on peroxidation and non-enzymatic glycation in diabetic rats

作　　者：钱萍萍[1] 郭俊生[2] 刘长云[1] 钮燕[3] 程胜求[2] 

机构地区：[1]解放军第411医院营养科,上海200081 [2]第二军医大学军队卫生学教研室 [3]海军医学研究所新药研究中心

出　　处：《卫生研究》2003年第5期446-448,共3页Journal of Hygiene Research

基　　金：国家自然科学基金资助 (No .39670 636)

摘　　要：为探讨铁在糖尿病及其并发症防治中的作用 ,以链脲佐菌素 (Streptozotocin ,STZ)腹腔注射SD大鼠建立糖尿病动物模型 ,在纯营养素饲料配方中加减元素铁 ,喂饲 5周 ,观察富铁及低铁饮食对糖尿病大鼠过氧化及非酶糖化的影响。结果表明富铁及低铁饮食对糖尿病大鼠体内糖化血红蛋白、糖化低密度脂蛋白及肾脏皮质的糖化终产物 (AGEs)含量无显著影响 ;低铁饮食对糖尿病大鼠血清和组织的脂质过氧化产物丙二醛 (MDA)含量无显著影响 ,富铁饮食可显著增高其血清及肾脏皮质的MDA含量。提示富铁及低铁饮食对糖尿病大鼠体内的非酶糖化作用无明显影响 ,但富铁饮食可以增强糖尿病大鼠体内的过氧化反应 。SD rats were peritoneally injected with streptozotocin to establish diabetes mellitus animal model. The changes of nonenzymatic glycation and peroxidation in rats supplemented with low iron or high iron during five weeks were investigated. It was found that MDA in serum or renal cortex but not glycated hemoglobin, glycated LDL, renal cortical AGEs increased significantly after supplementation of high iron in diabetic rats. There was no change in serum MDA, renal cortical MDA, glycated hemoglobin, glycated LDL and AGEs after supplementation of low iron in diabetic rats. The results suggested that peroxidation could be enhanced obviously by supplementation of high iron so that chronic complications could be promoted by high dose iron in diabetic rats.

关 键 词：糖尿病 非酶糖化 过氧化 铁 并发症 链脲佐菌素 

分 类 号：R587.1[医药卫生—内分泌] R994.4[医药卫生—内科学]