稀土暴露与儿童生长发育的相关性研究  

Study on relation between exposure to rare earth elements and physical growth and development of children

作　　者：范广勤[1] 郑辉烈[1] 刘勇[1] 袁兆康[1] 

机构地区：[1]江西医学院公共卫生学院,南昌330006

出　　处：《中国公共卫生》2003年第11期1283-1284,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金重点资助课题 (398690 0 3)

摘　　要：目的　探讨稀土暴露对儿童生长发育的影响。方法　在江西省某稀土矿区和对照区对 4 72名 7～ 10岁的儿童进行生长发育有关指标测量 ,并使用ICP -HS对 112名儿童血样进行稀土水平的测定 ;采用简单相关和多元回归等方法分析稀土负荷水平与儿童生长发育指标的关系。结果　稀土矿区儿童血稀土总量为 (2 18± 1 0 8)ng/ g ,是对照区 (1 2 6± 0 35 )ng/g的 1 73倍 ,有显著性差异。相关分析结果提示 ,血中稀土负荷水平与儿童的肺活量和血压 2指标均呈负相关 ;多因素分析显示 ,血中总稀土含量及母亲从事稀土作业情况被引入肺活量和血压 2指标的回归方程。Objective To study the effects of environmental exposure to rare earth elements (REEs) on physical growth and development of children. Methods Indicators for physical growth and development,su ch as body height and weight,vital capacity,blood pressure etc,were measured in sampled 472 children aged 7-10 years living in RE ore containing area and the co ntrol area in Xunwu county,Jiangxi.While fifteen kinds of REEs in 112 blood samp les (69 samples from exposure to REEs group and 43 samples from the control grou p) were determined by inductively coupled plasma soure mass spectrometry (ICP-MS s).Multiple regression analysis of blood REEs levels was conducted. Results The quantity of blood REEs of the children in the RE area was 1.73 times as that of the children in the control area.The differen ce was significantly great ( P <0 01).There were negative correlation shown b etween blood REEs levels and vital capacity,blood pressure in children.Multiple regression analysis showed that blood REEs levels and time of mother work in RE ore area were introduced into the vital capacity and blood pressure regression m odel respectiveiy. Conclusion Exposure to REEs could cause adverse effects o n their physical growth and development of children.

关 键 词：儿童 稀土 生长发育 肺活量 血压 相关性 

分 类 号：R179[医药卫生—妇幼卫生保健]