慢性前列腺炎患者前列腺液IL-6和IL-8表达变化及意义  

IL-6 and IL-8 levels in expressed prostate secretion of chronic prostatitis

作　　者：叶海云[1] 侯树坤[1] 白文俊[1] 邓庆平[1] 

机构地区：[1]北京大学人民医院泌尿外科,100044

出　　处：《中华泌尿外科杂志》2003年第4期279-281,共3页Chinese Journal of Urology

摘　　要：目的　探讨慢性前列腺炎患者前列腺液中IL 6和IL 8的变化与慢性前列腺炎类型、症状和前列腺液白细胞计数的相关关系。　方法　以两杯法尿液细菌培养、前列腺液常规检查和NIH CPSI评分 ,将 10 2例前列腺炎患者分型。放免分析法测定患者和 2 8例正常对照者前列腺液中IL 6和IL 8含量 ,比较结果并进行相关分析。　结果　 90例前列腺炎患者 (Ⅱ、ⅢA、Ⅳ型 )前列腺液IL 6和IL 8水平分别为 ( 0 .5 1± 0 .5 7)ng ml和 ( 10 .75± 7.96 )ng ml,高于正常对照组的 ( 0 .32± 0 .5 1)ng ml和( 4.5 6± 5 .6 8)ng ml(P <0 .0 5和P <0 .0 1)。Ⅱ型前列腺炎患者前列腺液IL 6和IL 8水平与ⅢA型和Ⅳ型者比较差别无显著性意义 (P >0 .0 5 )。前列腺炎患者前列腺液白细胞计数与IL 8水平呈正相关(r=0 .5 2 9,P <0 .0 1)。前列腺液IL 6和IL 8水平与NIH CPSI评分无相关性 (P >0 .0 5 )。　结论　慢性前列腺炎患者前列腺液IL 6和IL 8表达增高 ,并参与前列腺的炎症反应。前列腺液IL 6和IL 8水平可作为慢性前列腺炎的诊断依据之一。ObjectiveTo investigate the levels of anti-inflammatory cytokine IL-6 and pro-inflammatory cytokine IL-8 in expressed prostatic secretion(EPS)of chronic prostatitis.To study the relationship of cytokines to the mechanism of chronic prostatitis.MethodsIL-6 and IL-8 levels were measured in 102 chronic prostatitis EPS and in 28 normal EPS by radioimmunoassay.Urine was cultured and EPS was studied according to 2-glass test.NIH-CPSI(NIH-Chronic prostatitis symptom index) was performed by every patient.ResultsIL-6 and IL-8 levels were higher in Ⅱ,ⅢA and Ⅳ prostatitis (IL-6 0.51±0.57 ng/ml,IL-8 10.75±7.96 ng/ml,n=90) than those in controls (IL-6 0.32±0.51 ng/ml,IL-8 4.56±5.68 ng/ml,n=28),P<0.05 and P<0.01 respectively.There was no statistically significant difference between cytokines levels in Ⅱ prostatitis (n=36) and in ⅢA and IV prostatitis (n=54),P>0.05.There was a correlation between WBC count and IL-8 level,r=0.529,P<0.01,but no correlation between NIH-CPSI scores and cytokines levels,P>0.05.ConclusionsIL-6 and IL-8 are elevated in EPS of Ⅱ,ⅢA and IV prostatitis, and might be considered as mediators of inflammatory response in prostate.The results indicate that IL-6 and IL-8 can be the objective parameters in the diagnosis of chronic prostatitis.

关 键 词：慢性前列腺炎 前列腺液 IL-6 IL-8 表达 

分 类 号：R697.33[医药卫生—泌尿科学]