蓝紫光照射对烧伤大鼠免疫功能的影响  

Effects of blue-purple light irradiation on the immune fu ncti on in burned rats

作　　者：李凤敏[1] 马健 王伟[1] 王铮[1] 强茹玲[3] 周淑梅[1] 

机构地区：[1]天津医科大学总医院康复科,天津300052 [2]新疆体育局摔揉管理中心卫生室 [3]天津市激光技术研究所

出　　处：《中华物理医学与康复杂志》2003年第11期655-657,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：天津医科大学总医院青年基金资助项目 (No .9835)

摘　　要：目的　研究蓝紫光照射对烧伤大鼠免疫功能的影响。方法　将 48只大鼠随机分为正常对照组、烧伤对照组及烧伤蓝紫光照射治疗组 (治疗组 ) ,在烧伤对照组及烧伤蓝紫光组背部皮肤造成大鼠体表面积 (BSA) 2 0 %深Ⅱ度烧伤模型 ,并用蓝紫光对治疗组进行照射。测定烧伤后 3d、12d腹腔吞噬细胞吞噬活性、血清免疫球蛋白含量及肿瘤坏死因子细胞毒性的变化。结果　蓝紫光照射可以显著提高烧伤大鼠腹腔吞噬细胞的吞噬能力 ,并可提高烧伤大鼠血清IgA含量及调节血清中的TNF水平。结论　蓝紫光照射可通过提高大鼠腹腔吞噬细胞的吞噬能力、调节B 细胞功能、TNF水平来提高机体免疫力 。Objective To elucidate the effects of bl ue -purple light (BPL) irradiation on the immune function of burned rats. Methods48 adult Wistar rats were randomly divided into the BPL treatment group, burn control group, and normal control group after replica ting 20% BSA deep partial thickness burn models of rats. Changes in phagocytic i ndex, phagocytic rate, level of serum immunoglobin A,G,M and TNF from 3rd day an d 12th day after the burn were measured. ResultsAft er irradiation of BPL, the phagocytic index, phagocytic rate and level of serum immunoglobin A,G,M in burned rats were increased when compared with those of the control group. The level of serum TNF post-irradiation was higher than that of the normal control and lower than that of the burn control. Con clusionThe study suggested that BPL irradiation could improve immun e function in burned rats.

关 键 词：蓝紫光照射 烧伤 大鼠 免疫功能 影响 

分 类 号：R454.2[医药卫生—治疗学]