rIFNα-2b治疗慢性乙型肝炎中血清前S_1、S_2的动态变化  

THE CHANGE OF PRESl AND PRE S2 PROTEINS DURING RECOMBINANT INTERFERON ALPHA (rIFNα-2b) THERAPY IN CHRONIC HEPATITIS B PATIENTS.

作　　者：费国忠[1] 姚光弼[1] 

机构地区：[1]上海市静安区中心医院,上海200003

出　　处：《上海免疫学杂志》1992年第2期87-89,共3页Shanghai Journal of Immunology

摘　　要：本文对5例肝活检证实的慢性乙型肝炎病人在短程强的松龙撤除后应用重组干扰素α-2b治疗过程中对血清前S_1和前S_2蛋白进行了动态观察。疗程结束时,3例病人的血清前S_1、前S_2蛋白滴度逐渐下降,尤以前S_2蛋白的下降为明显,前S_1和前S_2蛋白的下降与DNAp、HBeAg的消失相关。另2例对此治疗无反应的病人,在治疗期间,血清前S_1和前S_2蛋白无明显变化,在治疗结束时,血清HBV-DNA,DNAp及HBeAg仍阳性。结果提示慢乙肝抗病毒治疗过程中,前S_1和前S_2蛋白的测定有助于监测疗效。Serum preS1 and preS2 protein levels were studied during antiviral treatment in 5 chronic hepatitis B (OHB) patients. The response was favourable in three patients with disappearance of HBeAg, HBV-DNA and DNAp as well as the emergence of anti-HBe. These changes were correlated with the lowering of titers of preS1 and preS2 proteins, especially the preS2 protein. The remaining two patients responded poorly with little change in all these parameters.

关 键 词：乙型肝炎 干扰素 前S蛋白 

分 类 号：R512.620.2[医药卫生—内科学]