初诊Graves病患者抑郁状态的分布特点及危险因素的研究  

Study on the characteristic distribution and risk factors of depression in patients with Graves' disease

作　　者：朱洁 任建民[2] 唐宽晓[2] 王德全[2] 许玲[2] 

机构地区：[1]山东省龙口市人民医院,山东龙口265701 [2]山东大学齐鲁医院内分泌科,山东济南250012

出　　处：《中国行为医学科学》2003年第5期527-529,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的　研究初诊Graves病 (GD)患者并发抑郁的分布特点及危险因素。方法　收集我院住院及门诊 2 0 0 0 .7～ 2 0 0 3 .4新诊断的GD患者 10 5 4名 ,采用流行病学调查一般方法对患者的一般资料、家庭功能、生活应激事件及抑郁等情况进行评定。以SPSS10 .0建立数据库 ,用描述性统计分析对分布特点进行统计 ;采用Logistic回归分析确定与抑郁状态有关的危险因素。结果　GD患者抑郁患病率为 61.9% ,男女分别为 70 .0 %、5 9.2 % ,多集中在 3 5～ 5 5岁 ;低文化、低经济收入的GD人群是并发抑郁的高发人群。GD患者抑郁患病与心率 (HR ,OR =11.2 68)、眼病 (GO ,OR =2 .3 67)、游离T3 (FT3 ,OR =1.5 62 )、TSH(OR =0 .980 )、家庭功能 (OR =0 .5 90 )及生活应激事件 (OR =2 .15 9)有明显相关性。结论　GD抑郁患病率高且性别存在差异 ,高年龄、低收入、低文化GD人群是GD并抑郁的高发人群 ,心率、眼病、FT3 及生活应激事件是GD患者并发抑郁状态的独立危险因素 ;家庭功能和TSH是GD患者并发抑郁的保护因素。Objective To explore the characteristic distribution and risk factors of major depression in patients with Graves disease. Methods We collected data of 1054 patients with Graves disease using the Common Item Table, the Smilkstein APGAR family function scale, the Stress Life Events, the Zung depression Scale, and analyzed data using Descriptives and multinomial logistic regression to demonstrate the characteristic distribution and risk facts of major depression in GD patients. Results Among 1054 GD patients, 652 people (61.9%) had major depression , at the same time ,the rate of male was 70.0% and the rate of female was 48.7%.The GD patients with depression were mostly 35～55 years old. The older people with GD who had lower earning and lower education have depression with GD easily. There were the obvious odds between heart rate, GO, the thyroid dysfunction, family function, life events and major depression. Conclusions The rate of GD with depression were higher than one of the other diseases, there was the obvious odds between sex. The heart rate, GO, FT3 and life events were risk factors for major depression with GD, while TSH and family function were protect factors.

关 键 词：GRAVES病 抑郁 

分 类 号：R395.1[哲学宗教—心理学]