条件反射性细胞免疫抑制及其作用时程的实验研究  

Time phases of conditioned cellular immunosuppression in rats

作　　者：李杰[1] 林文娟[2] 李波[1] 卫星[2] 

机构地区：[1]中国科学院心理研究所脑-行为研究中心,北京100101 [2]中国科学院心理健康重点实验室,北京100101

出　　处：《中国行为医学科学》2003年第5期481-483,共3页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金;中国科学院重点基金;中国科学院创新工程资助 (KSCX2 2 0 3)

摘　　要：目的　了解条件反射性免疫抑制作用及其作用时程的特点。方法　利用条件反射性免疫抑制的动物模型 ,以糖精水为条件刺激 (CS) ,免疫抑制剂 环磷酰胺为非条件刺激 (UCS)观察了两次性CS UCS条件结合训练后 ,再次呈现条件刺激诱导条件反射性味觉厌恶性反应 (CTA)和条件反射性免疫抑制 (CIS)对细胞免疫功能的动态调节作用。结果　CTA可以稳定形成直至第 3 0天 ,而在条件训练后再次给予条件刺激诱导CIS产生对细胞免疫功能的抑制作用在第 5天可观察到有明显的统计学意义的差异 ,而在第 15天表现为抑制作用减弱及第 3 0天消退的现象。结论　味觉厌恶行条件反射和条件反射性免疫抑制反应在表现时程效应和表现方式上并不同步 ,条件反射性免疫抑制反应并不是味觉厌恶性条件反射的伴随反应 ,两者在脑中的调节机制可能相互各自独立。Objective To understand the nature of the conditioned immunosuppression (CIS) and examine the time phase of CIS and conditioned taste aversion (CTA). Methods Cyclophosphamide was used as an unconditioned stimulus (UCS) and saccharin was used as the conditioned stimulus (CS). Both CTA and CIS as assessed by cell proliferation were examined by one re-exposure to CS at intervals of 5, 15, 30 days after two trials of CS-UCS pairing. Result CTA occurred and the level remained at the every interval testing. However, CIS occurred obviously only on the 5th day after conditioning. CIS was attenuated on the 15th day and disappeared on the 30th day after conditioning. Conclusion There was no association between the conditioned immunosuppression and the conditioned taste aversion. Both of them have their own modulation mechanism in the center nervous system.

关 键 词：条件反射性免疫抑制 细胞免疫 时程效应 大鼠 

分 类 号：R392[医药卫生—免疫学]