4-(N-异丙氨基)-苯甲酸的合成研究  

Study on Synthesis of 4-(N-Isopropylamino)-benzoic Acid

作　　者：陈兆斌[1] 冯丽恒[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006

出　　处：《化学世界》2003年第11期582-584,共3页Chemical World

基　　金：国家自然科学基金(30000112);山西省归国留学人员科研基金(晋留2001-1)资助项目。

摘　　要：对分子中既具有吸电子基,又具有给电子基的化合物4-(N-异丙氨基)-苯甲酸进行了合成,具体的合成步骤和反应条件为:50mL水中加入3g(0.022mol)对氨基苯甲酸,再加入无水碳酸钾1.5g(0.011mol),调整pH约为8,使成羧酸盐,经过滤后加入2-溴丙烷2.5g(0.02mol),加热回流12h,直至下层的2-溴丙烷基本消失,冷却,得灰白色固体,重结晶并用活性炭脱色,得白色晶体4-(N-异丙氨基)-苯甲酸。4(Nisopropylamino)benzoic acid containing both electronattracting groups and electronreleasing groups was synthesized from paminobenzoic acid by alkylation reaction. The reaction procedures and conditions were as follows: First, 3 g(0.022 mol)paminobenzoic acid and 1.5 g(0.011 mol) potassium carbonate were added into 50 mL water and the reaction system was adjusted to pH=8 to get the salt of paminobenzoic acid. Second, 2.5 g (0.02 mol) 2bromopropane was added to the reaction system and the reaction mixture was refluxed for 12 h until the 2bromopropane in the bottom disappeaed. The reaction mixture was cooled to give a greyish white solid. At last, the solid was recrystalliged to obtain the title product, 4(Nisopropylamino)benzoic acid.

关 键 词：对氨基苯甲酸 2-溴丙烷 4-(N-异丙氨基)-苯甲酸 烷基化反应 

分 类 号：O621.3[理学—有机化学]