心力衰竭引起血栓前状态的机制的探讨  

The changes of plasma PAI-1 and GMP-140 and vWF in patients with congestive heart failure

作　　者：陈世德[1] 陶新智[1] 

机构地区：[1]广西医科大学心血管病研究所,南宁530021

出　　处：《临床心血管病杂志》2003年第11期658-659,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究充血性心力衰竭 (CHF)是否引起血栓前状态及其机制。方法 :采用酶联免疫吸附法(ELISA)测定 6 0例CHF患者及 2 0例健康人血浆纤溶酶原激活物抑制物 1(PAI 1)、血小板α颗粒膜蛋白 14 0(GMP 14 0 )、血管性血友病因子 (vWF)抗原水平。结果 :CHF患者血浆PAI 1、GMP 14 0、vWF抗原水平均较正常对照者明显增高 ,并且与心功能状态有关。结论 :CHF患者存在纤溶活性降低、血小板活性增高、内皮功能受损 ,均与CHF时血栓发生率增高有关。Objective:The aim of this study is to investigate whether congestive heart failure(CHF) can cause prothrombosis state,and to explore its mechanism.Methods:Enzyme-linked immunosorbent assay(ELISA) was used to measure plasma plasminogen activator inhibitor-1(PAI-1), platelet alpha-granule membrane protein-140(GMP-140) and von Willebrand factor(vWF) in 60 patients with CHF and in 20 normal controls.Results:Compared with the healthy subjects, the levels of plasma PAI-1、GMP-140 and vWF in patients with CHF were significantly increased and related to the cardiac function.Conclusion:The decrease of fibrinolytic activity, platelet activation and endothelial dysfunction may play an important role in the prothrombosis state of heart failure.

关 键 词：心力衰竭 充血性 纤溶酶原激活物抑制物-1 Α颗粒膜蛋白-140 血管性血友病因子 

分 类 号：R541.6[医药卫生—心血管疾病]