冠心病患者血浆纤溶酶原激活物抑制物-1水平的变化  

The plasma PAI-1 antigen level and the risk of coronary artery disease in Chinese

作　　者：戴研[1] 高润霖[1] 陈纪林[1] 吴永健[1] 刘海波[1] 秦学文[1] 贾云香[1] 孙继良[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所北京阜外心血管病医院冠心病研究室,北京100037

出　　处：《临床心血管病杂志》2003年第11期660-662,共3页Journal of Clinical Cardiology

摘　　要：目的 :探讨纤溶酶原激活物抑制物 1(PAI 1)与冠心病及其不同临床亚型的相关性及其与冠状动脉病变程度的关系。方法 :选择 345例非糖尿病的住院患者 (其中 2 95例已行冠状动脉造影 ) ,分为对照组和冠心病组 ,测定血浆PAI 1抗原水平。结果 :血浆PAI 1抗原水平在对照组与冠心病组间无统计学差异。与稳定型心绞痛组 (SAP)相比 ,不稳定型心绞痛 (UAP)患者PAI 1水平显著升高 [(2 5 .0± 7.2 ) μg/L比 (2 2 .3± 7.1) μg/L ,P <0 .0 5 ],经Logistic回归分析 ,PAI 1水平与UAP仍有显著性相关 ,调整后的OR值为1.83(P <0 .0 5 )。PAI 1血浆水平与冠状动脉病变支数无关。结论 :血浆PAI 1抗原水平升高可能与UAP有关 ,但与冠心病的发生无关 ,且对冠状动脉病变范围无预测价值。Objective:To assess whether the PAI-1 plasma antigen level is associated with coronary artery disease (CAD) and the extent of the coronary atherosclerosis. Methods:Blood was drawn from 345 patients from Fuwai Hospital (295 patients undergoing coronary angiography). The PAI-1 antigen level was determined with ELISA. Results:There was no difference in plasma PAI-1 antigen level between the control group and the CAD group. Nevertheless, the PAI-1 level is higher in the unstable-angina pectoris (UAP) group than the stable-angina pectoris (SAP) group [( 25.0± 7.2)μg/L vs ( 22.3± 7.1)μg/L, P< 0.05]. In Logistic regression analysis, the plasma PAI-1 level was associated with the UAP (the adjusted OR value is 1.83, P< 0.05). The plasma PAI-1 level was not associated with the extent of the coronary atherosclerosis. Conclusion:Although the plasma PAI-1 level was associated with UAP, it was not related with the extent of the coronary atherosclerosis.

关 键 词：冠状动脉疾病 纤溶酶原激活物抑制物-1 

分 类 号：R543.3[医药卫生—心血管疾病]