气相色谱法测定无极膏中薄荷脑,樟脑和水杨酸甲酯的含量  

Determination of menthol, camphor and methylsalicylate in Cremor-Mentholi Compositus by GC

作　　者：吴琼珠[1] 戴永健[1] 刘卫卫[1] 

机构地区：[1]第二军医大学南京军医学院,江苏南京210099

出　　处：《中成药》2003年第11期879-882,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :建立气相色谱法测定无极膏中薄荷脑、樟脑及水杨酸甲酯的含量。方法 :以聚乙二醇 2 0M为固定液相 ,涂布浓度为 10 % ,柱温为 14 0℃ ,氢火焰离子化检测器 ,检测器温度为 2 6 0℃。结果 :3组分GC法测定的分离度和线性关系良好 ,回收率分别为薄荷脑 10 0 .17% ,RSD =0 .6 6 1% ;樟脑 99.89% ,RSD =0 .6 0 0 % ;水杨酸甲酯 10 0 .17% ,RSD =0 .5 5 3%。结论 :本法灵敏、快速、准确 ,可作为无极膏的质量控制标准。Objective: To establish a GC method for determination of menthol, camphor and methylsalicylate in Cremor Mentholi Compositus. Methods: The determination was carried out on a PEG\|20M stainless steel column with temperature at 140℃, FID detector with temperature at 260℃. Results: The separating degree and the linearity were fine with the average recovery of menthol 100.17%, RSD =0.661%; camphor 99.89%, RSD =0.600%; methylsalicylate 100.17%, RSD =0.553%, respectively. Conclusions: The method is convenient, rapid and accurate. It can be used to control the quality of this preparation.

关 键 词：无极膏 含量测定 气相色谱法 薄荷脑 樟脑 水杨酸甲酯 

分 类 号：R283.621[医药卫生—中药学]