BSO对体外人体肿瘤细胞株作用的实验研究  

EXPERIMENTAL STUDY ON ANTITUMOURAL EFFECT OF BUTHIONINE SULFOXIMINE (BSO) ON HUMAN TUMOR CELL LINES IN VITRO

作　　者：金杏泉[1] 陆婉琴[1] 徐静芳[1] 金一尊[2] 周建议[2] 季华钧[2] 

机构地区：[1]上海医科大学肿瘤研究所临床药理研究室 [2]上海医科大学放射医学研究所

出　　处：《上海医科大学学报》1992年第1期46-50,共5页Journal of Fudan University(Medical Science)

基　　金：国家自然科学基金;编号3880290

摘　　要：用体外实验方法,以人红白血病K562,人胃癌细胞株SGC-7901为靶细胞,研究丁胱亚磺酰亚胺(BSO)对人体肿瘤细胞的直接杀伤及BSO与顺氯氨铂(DDP)或5-氟尿嘧啶(5Fu)联合应用的增敏作用。结果表明BSO单用或与DDP、5Fu联合应用对K562和SGC-7901均有明显的杀伤作用。Buthionine sulfoximine (BSO), a selective inhibitor of r-glutamyloysteine synthetase and thus an inhibitor of GSH (Glutathione) biosynthesis, has been studied as a ohemosensitizer.We have investigated its effect on two human tumor cell lines in vitro. The results showed that BSO(0.01-50μg/ml) had remarkable oytostatio activity on human leukemia K 562 and human gastric cancer SGC-7901.As a ehemosensitizer, it may potentiate or enhance their antitumour activity on K 562 and SGG-7901 when used in combination with fluorouracil (5 FU) or ois-diaminediohloroplatin (DDP). On the basis of these data, we reoommend further preolinioal study.

关 键 词：人红白血病 人胃癌细胞株 BSO 

分 类 号：R979.1[医药卫生—药品]