米利酮对麻醉家兔的心血管作用  

CARDIOVASCULAR EFFECTS OF MILRINONE IN ANESTHESIZED RABBITS

作　　者：沙群[1] 周思平[1] 蒋美芬[1] 沈筱同[1] 

机构地区：[1]上海医科大学基础医学部药理学教研室

出　　处：《上海医科大学学报》1992年第3期178-182,共5页Journal of Fudan University(Medical Science)

基　　金：上海市科学技术发展基金893430110

摘　　要：静脉注射米利酮(3～300μg/kg),能使麻醉家兔正常心脏左室内压最大上升和下降速率(LV士dP/dt max)呈剂量依赖性增加,心率(HR)仅在高剂量时略有增加,而全身动脉压(AP)无明显变化。米利酮在静脉剂量300μg/kg才增加呼吸振幅和频率。给家兔灌胃米利酮(10mg/kg,2次/d)一周后,其心脏收缩和舒张功能均显著高于对照组。米利酮(500μg/kg iv)可明显翻转家兔戊巴比妥钠诱导的衰竭心脏血流动力学指标,AP亦无变化。结果表明,米利酮对家兔正常和衰竭心脏都有明显的正性肌力作用,且在这些剂量不改变心脏后负荷。Intravenous administration of milrinone in doses of 3-300μg/kg to anesthe-sized rabbits results in a dose-related increase in left ventricular pressure (LVP) + dP/dt max and - dP/dt max, a relatively small increase in heart rate (HR) at higher doses and no significant change in arterial blood pressure (AP) . Milrinone above 300μg/kg caused an increase in the amplitude and frequency of respiration in rabbits. After 7 days of oral administration of milrinone (10mg/kg, twice a day) to rabbits, then the ane sthesized rabbits showed increase in systolic and diastolic function which were significant when compared with control group. An intravenous dose of 500μg/kg milrinone reversed the hemodynamic parameters of rabbits with pentobarbital-induced heart failure, but no change in AP. The present results suggest a significant inotropic effect on normal and the experimented failing heart in rabbits, no change in cardiac afterload was observed at these dose levels.

关 键 词：米利酮 血流动力学 心力衰竭 

分 类 号：R972.1[医药卫生—药品]