左旋吡喹酮对感染小鼠体内日本血吸虫体表皮层损害的效应  

LEVO PRAZIQUANTEL EFFECTS ON TEGUMENTALDAMAGE IN SCHISTOSOMA JAPONICUMINFECTED MICE

作　　者：程训佳[1] 黄美玉[1] 

机构地区：[1]上海医科大学基础医学部寄生虫学教研室

出　　处：《上海医科大学学报》1992年第5期367-369,共3页Journal of Fudan University(Medical Science)

基　　金：联合国开发计划署;世界卫生组织热带病研究培训特别规划;罗氏基金会(T16;181;164 880280)

摘　　要：感染日本血吸虫的小鼠1次口服75mg/kg的左旋吡喹酮(LPQ)或150mg/kg的消旋吡喹酮(PZQ)3～36d后不同时间取虫,常规石蜡切片染色观察。结果显示用药后,虫体体表皮层出现水肿和空泡;有些虫体空泡较大或空泡破裂,皮层组织紊乱;部分虫体皮层离散或体壁肌层暴露;甚至出现环肌层水肿;有絮状物粘附在皮层上,以抱雌沟处尤为明显。雌雄成虫体表皮层损害的程度没有区别。停药后7周虫体体表开始修复。提示LPQ与PZQ一样,可致血吸虫成虫皮层代谢障碍,进而激活宿主的免疫反应,但确切原因有待进一步研究。Mice, infected with Schistosoma japonicum, were treated with a single oral dose of levo-praziquantel 75mg/kg or raoemic praziquantel 150mg/kg and were killed 3-63 days after treatment. The parasites were collected by perfusing portalmesen-terio veins and liver. The schistosomes were fixed with 10% formalin. Paraffin sections were made and stained with HE. Results showed that the worm tegument appeared edematous with extensive vacuolation, some showing large vacuolation and rupture. The tegument in some worms showed disorderly destruction and lesfl with exposure of layer. The circular muscular layer were occasionally edematous. At the same time, there was some exudate adhering to the tegument. Tegumental damage in the male and female worms were similar. 7 weeks after treatment, the tegumental to repair began. It is thus demonstrated that levo-praziquantel given as racemio praziquantel could cause metabolic disturbances of the tegument appearing as immunological lesions. The precise mechanism needs to be further investigated.

关 键 词：左旋吡喹酮 日本血吸虫 皮层 

分 类 号：R383.24[医药卫生—医学寄生虫学]