新的血清游离雌三醇测定产前监护围产儿健康的评价  

EVALUATION OF ANTENATAL MONITORING OF FETAL WELL-BEING BY DETERMINATION OF UNCONJUATED SERUM ESTRIOL

作　　者：赵右更[1] 蒋文妹[1] 沈歈忱[1] 李道贞[1] 沙云龙[2] 李明娟[2] 

机构地区：[1]中国福利会国际和平妇幼保健院 [2]卫生部上海生物制品研究所放射免疫研究室

出　　处：《上海医学》1992年第2期87-91,共5页Shanghai Medical Journal

摘　　要：应用新研制的雌三醇(E_3)-放射免疫药盒测定妊娠≤13～41周2611例正常孕妇的血清游离E_3值,显示血E_3值随孕周的增加而升高;以第2.5百分位数作为正常下限值。以此产前监护457例中晚期妊娠(正常和高危妊娠各212及245例),血E_3测定结果呈现假阴性与假阳性率分别为2.2％及0.4％,纠正已报道12小时尿E_3/C的这二率各是32.2％及96.6％。12例低血E_3值中,国产儿死亡8例,而正常血E_3值445例中,除1例因脐绕颈致死外,无1例围产儿死亡。文中强调了连续测定的重要性。初步结果提示采用这一新E_3药盒测定血清E_3值,是产前监护围产儿健康的一项更为实用与可靠的方法。A maternal unconjugated serum estriol (E_3) determination radioimmunoassay kit was used to monitor 457 fetuses of 22—42 weeks gestation in 212 normal and 245 high-risk pregnancies. The normal pregnancy serum E3 values were also measured in 2611 cases of the ≤13th to 42nd gestational week. Normal values of serum E3 from the ≤13th to 42nd gestational week and normal low-limit in every week had been established. The results revealed that the false negative and false positive rates of serum E3 were 2.2% and 0.4% respectively, In 12 cases with low serum E3 there were 8 fetal deaths; whereas in 445 cases with normal serum E3, only one fetus died of nuchal cord, and no perinatal death occurred. It is emphasized that consecutive measurement of serum E3 is of significant importance. Furthermore our preliminary observation suggests that determination of serum E3 is more reliable and practical in the monitorng of fetal well-being.

关 键 词：血清 游离E5 围产儿 

分 类 号：R715.3[医药卫生—妇产科学]