重型病毒性肝炎患者支链和芳香氨基酸代谢动力学的研究  

STUDY ON THE METABOLIC KINETICS OF BRANCHED CHAIN AMINO ACIDS AND AROMATIC AMINO ACIDS IN PATIENTS WITH SEVERE VIRAL HEPATITIS

作　　者：周霞秋[1] 沈耕荣[1] 严振宜[1] 徐鹏程[1] 夏宗勤[2] 戴腾昌[2] 俞炳耀[2] 张建华[2] 

机构地区：[1]上海第二医科大学附属瑞金医院传染病科 [2]上海第二医科大学基础医学院同位素室

出　　处：《上海医学》1992年第3期144-146,共3页Shanghai Medical Journal

摘　　要：作者用4种稳定性核素标记的支链氨基酸和芳香氨基酸对正常人与重型病毒性肝炎(重型肝炎)患者进行示踪动力学的研究。结果显示重型肝炎患者苯丙氨酸的血浆代谢库增大,而3种支链氯基酸的血浆库则减少。因此为了有效地纠正肝病时血浆氨基酸的不平衡,一方面需采用氨基酸制剂滴注疗法,另一方面还需采取措施减少支链氨基酸的降解。The metabolic kinetics of branched chain amino acids (BCAA) and aromatic amino acids (AAA) in normal subjects and patients with severe viral hepatitis as studied with 4 stable isotope labeled tracers. The results indicated that the plasmatic pool size of Phe was increased and those of ECAA (Val, Leu, ILe) were decreased in severe viral hepatitis. This suggested that BCAA enriched infusion is valuable and may decrease the degradation of BCAA.

关 键 词：重症肝炎 代谢动力学 放射性核素 

分 类 号：R512.6[医药卫生—内科学]