吸入丙酸培氯松对支气管哮喘患者气道反应性的影响  

EFFECT OF INHALED BECLOMETHASONE DIPROPIONATE ON AIRWAY RESPONSIVENESS IN ASTHMATICS

作　　者：沈勋[1] 蔡映云[1] 张志凤[1] 钮善福[1] 

机构地区：[1]上海医科大学附属中山医院肺病学教研室

出　　处：《上海医学》1992年第6期322-324,共3页Shanghai Medical Journal

摘　　要：本文采用随机、单盲对照的设计方法,就19例支气管哮喘患者吸入丙酸培氯松或安慰剂对气道反应性的影响进行了观察。结果显示9例患者吸入激素300～450μg/d后,气道反应性明显降低,阈剂量(D_(min))几何均数从0.116U增至0.658U(P<0.01)。而10例吸入安慰剂的患者,气道反应性未见明显变化,D_(min)吸药前后分别为0.220U和0.328U(P>0.05)。提示吸入丙酸培氯松能降低支气管哮喘患者的气道反应性。In a single-blind, placebo-controlled and randomized study, the effect of inhaled beclomethasone dipropionate (BDP) on airway responsiveness was observed in 19 asthmatics. Airway responsiveness was to methacholine was measured with Astograph method. The results showed that airway responsiveness reduced in the BDP group, whereas no change occurredin the placebo group. The geometric mean of the amount of cumulative dose (D_(min)) incre ased significantly from 0.116u to 0.658u (p<0.01) in 9 cases treated with BDP aerosol (300—450μg/day). The geometric means of D_(min) in 10 cases treated with placebo were 0.220u and 0.328u before and after inhalation respectively (p>0.05). The data showed that inhaled BDP could reduce airway responsiveness.

关 键 词：气道反应性 丙酸培氯松 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]