基质金属蛋白酶与肺癌转移的关系  

MATRIX METALLOPROTEINASES AND METASTASIS OF LUNG CANCER

作　　者：刘瑾[1] 杨青[1] 王绵珍[1] 兰亚佳[1] 

机构地区：[1]四川大学华西医学中心公共卫生学院劳动卫生教研室,610041

出　　处：《现代预防医学》2003年第5期689-693,696,共6页Modern Preventive Medicine

基　　金：美国纽约中华医学会四川省科委资助项目

摘　　要：基质金属蛋白酶 (m atrix m etalloproteinases,MMPs)是一组锌离子依赖的蛋白水解酶 ,在 ECM降解中起着重要作用。目前研究表明 ,MMPs活性异常不仅能促进肿瘤血管形成 ,还是人类多种肿瘤侵袭和转移的必要条件。本文就与肺癌侵袭和转移有关的Matrix metalloproteinases(MMPs)are a group of Zinc-dependent proteolytic enzymes,playing essential roles in the degradation of the extracellular matrix(ECM) MMPs have been implicated in processes leading to the invasion and metastasis of human cancers Evidences suggest that they also play a role in tumor neovascularization This articles review the studies of MMPs' role in invasion and metastasis of lung cancer

关 键 词：基质金属蛋白酶 肺癌转移 肺癌侵袭 MMPS 细胞因子 

分 类 号：R734.2[医药卫生—肿瘤]