复方苦参碱注射液对肝纤维化大鼠血清中白细胞介素1β水平的影响  

Effect of matrine compound injection on interleukin-1β level in serum of rat with liver fibrosis

作　　者：宋春辉[1] 万谟彬[1] 朱伟[1] 郭品娥[2] 

机构地区：[1]第二军医大学长海医院感染科,上海200433 [2]长海医院实验诊断科

出　　处：《第二军医大学学报》2003年第10期1105-1107,共3页Academic Journal of Second Military Medical University

基　　金：上海市重大医学发展重点课题基金(99ZDI001).

摘　　要：目的:研究复方苦参碱注射液防治肝纤维化的作用及其机制。方法:应用四氯化碳诱导大鼠实验性肝纤维化,并以复方苦参碱注射液进行防治,观察4、6、9周模型组和治疗组的肝功能指标、IL-1β及病理变化。结果:模型组和治疗组血清中IL-1β浓度在实验4周时分别为(25.51±14.31)和(10.49±7.49)pg/ml;6周时为(109.67±20.87)和(1 5.06±2.65)pg/ml;9周时为(40.26±10.63)和(23.27±7.56)pg/ml,组间差异均有显著性(P<0.05,P<0.01);各时间点肝功能指标(ALT、AST、TBil)在治疗组均明显好于模型组;病理切片显示,各时间点的组织炎性细胞浸润、肝细胞坏死程度及纤维间隔形成程度,治疗组均好于模型组(P<0.05,P<0.01)。结论:复方苦参碱注射液有防治四氯化碳诱发的肝纤维化的作用,其机制与抑制单核巨噬细胞分泌IL-1β有关。Objective:To study the anti-fibrogenetic effect of matrine compound injection and its mechanism. Methods: Experimental liver fibrosis induced by tetrachloride in rats was treated by matrine compound injection. Liver function index, interleukin-1β (IL-1β) and pathological changes in liver tissue were observed in model and therapy groups during the 4th,6th and 9th week. Results:The serum IL-1β levels of model and therapy groups were (25. 51±14. 31) and (10. 49±7. 49) pg/ml in the 4th week, (109. 67±20. 87) and (15. 06±2. 65) pg/ml in the 6th week, and (40. 26±10. 63) and (23. 27±7. 56) pg/ml in the 9th week. The liver function (ALT, AST, TBil) of therapy group was better than that of model group at each stage. Pathological changes indicated that the infiltration of inflammatory cells,the degree of liver cell necrosis and the degree of fi-broplastic proliferation in the therapy group were obviously better than those of the model group. Conclusion : Matrine compound injection has an anti-fibrogenetic action on the liver fibrosis induced by tetrachloride.

关 键 词：肝纤维化 复方苦参碱注射液 大鼠 血清 白细胞介素1Β 预防 治疗 

分 类 号：R259.752[医药卫生—中西医结合]