补充支链氨基酸对运动大鼠脑及血小板5-HT_(2A)受体与螺环哌丁苯结合影响的研究  

Effect of Supplement of BCAA on [3H] Spiperone Binding to Serotonin2A Receptors of Brain and Platelets in Training Rats

作　　者：邱卓君 季健民 黄园 卢汉平[2] 许豪文[3] 

机构地区：[1]广东省体育科学研究所,广州510100 [2]中山大学医学院核医学实验室 [3]华东师范大学体育与健康学院

出　　处：《中国运动医学杂志》2003年第5期449-452,457,共5页Chinese Journal of Sports Medicine

摘　　要：采用放射标记受体测定技术观察补充支链氨基酸 (BCAA)或BCAA +CHO对SD大鼠一次性运动以及 3周耐力训练后的一次性运动前后血小板以及脑 5 -HT2A受体与 [3H]Spiperone(螺环哌丁苯 )结合的影响 ,结果表明 :急性耐力运动可导致SD大鼠脑 5 -HT浓度的增加 ,并且导致血小板以及脑 5 -HT2A受体下调 ,大鼠 3周耐力训练期间补充BCAA +CHO有防止由耐力运动引起的 5-HT2A受体密度下调的作用 ,长期耐力训练期间补充BCAA +CHO对延缓中枢疲劳有积极的作用。SD rats were sampled and spiperone binding to serotonin2A receptors on brain and platelets were tested before and after a section training or long-term(3 weeks) intensive training using radiolabeled receptor assay. Results showed that there were significant increment of concentration of 5-HT in brain and decrease of 5-HT 2A R density in specific binding sites(B max ) on membranes of brain and platelets post acute intensive exercise. The downregulation of B max of 5-HT 2A R could be prevented by the supplement of BCAA+CHO during 3 weeks' intensive training. There was a positive effect on the delay of central fatigue with the supplement of BCAA+CHO during long-term intensive exercise.

关 键 词：运动大鼠 脑 血小板 5-HT2A受体 螺环哌丁苯 影响 支链氨基酸 

分 类 号：R87[医药卫生—运动医学]