苄丙酮香豆素对实验性大鼠肾草酸钙结石形成的影响  

Effect of warfarin on experimental calcium oxalate stone formation in rats

作　　者：李浩勇[1] 李凯[2] 刘继红[1] 曹正国[1] 王少刚[1] 蔡丹[1] 叶章群[1] 章咏裳[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科 [2]广东中山市陈星海医院泌尿外科

出　　处：《中华泌尿外科杂志》2003年第10期663-665,共3页Chinese Journal of Urology

基　　金：国家自然科学基金 ( 3 9970 740 );国家教委基金 [(教外司留 1996) 64 4号 ];武汉市青年科技晨光计划 ( 975 0 0 60 95 )

摘　　要：目的　探讨Vit.K拮抗剂苄丙酮香豆素 (商品名华法令 )对大鼠肾草酸钙结石形成的影响。　方法　采用乙二醇饮水和氯化铵灌胃作成石剂 ,30只Wistar大鼠随机分为对照组 (A组 )、成石组 (B组 )、华法令组 (C组 )。饲养 4周后 ,检测大鼠肾组织钙含量和草酸钙晶体形成、2 4h尿钙、尿草酸含量及血生化指标。　结果　成石组和华法令组肾组织中钙、镁含量 ,2 4h尿草酸及尿钙、镁排泄量差异无显著性意义 ;镜下观察发现 :华法令组大鼠肾脏草酸钙结晶形成多于成石组 ,但组间比较差异无显著性意义。　结论　苄丙酮香豆素对大鼠肾草酸钙结石的形成无显著影响。Objective To investigate the effect of warfarin on the formation of renal calcium oxalate stones induced by 1% ethylence glycol (EG) and 3% ammonium chloride (NH 4Cl) in rats. Methods 30 adult male Wistar rats were randomized to three groups,the control group (A) being non-treated,the stone group (B) rats taken EG and NH 4Cl,and the warfarin group (C) taken warfarin in addition to EG and NH 4Cl.All rats were bred 4 weeks.The renal tissue calcium,the renal calcium oxalate crystallization,and the urinary calcium excretion and serum biochemical data were detected. Results No significant difference has been noted in 3 groups,although there is a tend that number of ranal calcium oxalate crystals in group C was more than that in group B. Conclusions The results denoted that warfarin had no significant effect on the calcium oxalate crystallization in rats.

关 键 词：苄丙酮香豆素 大鼠 肾草酸钙结石形成 影响 肾结石 

分 类 号：R691.4[医药卫生—泌尿科学]