低频复合脉冲电流对蟾酥经皮吸收的动态影响  

Dynamic Effect of Low Frequency Complex Impulse Current on Transdermal Absorption of Secretio Bufonis

作　　者：苏永华[1] 牛欣[1] 杨学智[1] 张胜[1] 程薇[1] 席时芳[1] 

机构地区：[1]北京中医药大学

出　　处：《中国中西医结合杂志》2003年第10期760-762,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：教育部骨干教师 (振兴行动计划 )课题;国家中医药管理局资助课题 (No .2 0 0 0 J P 2 7)

摘　　要：目的 :考察蟾酥的经皮吸收规律以及低频复合脉冲电流对蟾酥经皮吸收的影响。方法 :采用水平式三室离体经皮流通扩散池 ,用高效液相色谱仪测定蟾酥中蟾毒灵、华蟾酥毒基及脂蟾毒配基等成分的经皮吸收量并计算经皮吸收速率。结果 :蟾酥中主要成分可经皮吸收 ,但皮肤透过量较少 ,外加低频复合脉冲电流可明显提高蟾酥主要成分经皮吸收的累积渗透量和经皮扩散速率 ,2h后出现差异 ,4h后差异显著。13 8Hz促进蟾酥经皮吸收的效果较好。结论 :蟾酥的主要成分可以通过皮肤给药被吸收 ,低频复合脉冲电流可显著提高蟾酥的经皮吸收量和经皮吸收速率。Objective: To explore the regulation of transdermal absorption of Secretio Bufonis (SB) and the effect of low frequency complex impulse current (LFCIC) on it. Methods: By modifying three-chamber flow diffusion pool to develop a prototype LFCIC device for transdermal delivery, using high performance liquid chromatograph (HPLC) to determine the quantitative transdermal absorption of the amount of ingredients of SB, including bufalin, cinobufagin and resibufogenin, etc. and the transdermal absorption velocity was calculated. Results: The chief ingredients of SB could be absorbed through skin, but the volume was low. Additional application of LFCIC could enhance the cumulative infiltration volume and velocity of transdermal diffusion. Difference appeared 2 hrs after and significant difference appeared 4 hrs after the application, and 13.8 Hz showed the optimal effect of transdermal delivery. Conclusion: Chief ingredients of SB could be absorbed through transdermal medication, and LFCIC can evidently enhance the amount and velocity of transdermal absorption of SB.

关 键 词：低频复合脉冲电流 蟾酥 经皮吸收 动态影响 

分 类 号：R285[医药卫生—中药学]