7种抗菌药物对金黄色葡萄球菌及大肠杆菌体外抗生素后效应的研究  

Study on the postantibiotic effect of seven antimicrobial agents against S.aureus and E.coil

作　　者：伍金娥[1] 李德学[2] 王大菊[1] 

机构地区：[1]华中农业大学兽药研究所,湖北武汉430070 [2]湖北省畜牧局,湖北武汉430070

出　　处：《中国兽药杂志》2003年第10期30-32,共3页Chinese Journal of Veterinary Drug

摘　　要：　采用稀释法去除抗生素,用菌落计数测定细菌生长曲线的方法测定环丙沙星、洛美沙星、诺氟沙星、恩诺沙星、庆大霉素、青霉素及氨苄西林对金葡球菌及大肠杆菌的抗生素后效应(PAE)。结果:几种药物在各浓度组对金黄色葡萄球菌均呈现明显的PAE,氟喹诺酮类药物及庆大霉素对大肠杆菌产生较长的PAE,而β内酰胺类药物作用后的PAE则很短。PAE的存在提示:在兽医临床设计给药方案时,适当延长给药间隔时间,减少给药次数,仍能维持抗菌效果。The in vitro postantibiotic effects (PAE) of ciprofloxacin, lomefloxacin, norfloxacin, enrofloxacin, gentamycin, penicillin and ampicillin against S.aureus and E.coil were detected. Dilution method was used instead of removing drugs. The growth of bacteria was monitored by MuelleHinton agar colony counting. The results showed that seven drugs had obvious PAE on S.aureus, quinolones and gentamycin had long PAE on E.coil, but βlactam drugs had very short PAE.

关 键 词：抗菌药物 金黄色葡萄球菌 大肠杆菌 抗生素后效应 

分 类 号：S859.796[农业科学—临床兽医学]