慢性肝病与β_2糖蛋白Ⅰ抗体及其他自身抗体的关系  

Study of relationship between some autoantibodies and chronic liver disease

作　　者：高普均[1] 朴云峰[1] 曲立科[2] 时阳[1] 杨翰仪[2] 

机构地区：[1]吉林大学第一临床学院消化科,长春130021 [2]吉林大学基础医学院生物化学教研室

出　　处：《中华消化杂志》2003年第5期301-303,共3页Chinese Journal of Digestion

基　　金：国家自然科学基金资助项目 ( 3 0 0 70 3 3 8)

摘　　要：目的　研究 β2 糖蛋白Ⅰ (β2 GPⅠ )抗体及抗双链DNA抗体 (ds DNA)、抗平滑肌抗体(SMA)、抗核糖核蛋白抗体 (RNPA)与慢性肝病的相关性。方法　选择明确诊断的慢性乙型肝炎和乙型肝炎后肝硬化患者为研究对象 ,采用ELISA法 ,以纯化的人 β2 GPⅠ为抗原 ,检测这些患者血清中β2 GPⅠ抗体水平 ,同时检测ds DNA、SMA、RNPA的血清水平。结果　乙型肝炎后肝硬化患者血清中β2 GPⅠ抗体水平与对照组相比明显升高 (P <0 .0 1) ,患者血清中 β2 GPⅠ抗体高于慢性乙型肝炎组 (P <0 .0 5 ) ;并且发现慢性乙型肝病患者 β2 GPⅠ抗体的阳性率高于其他自身抗体。结论　乙型肝炎病毒(HBV)感染与 β2 GPⅠ抗体的产生可能相关 ,推测 β2 GPⅠ参与HBV感染的病理过程。Objective To investigate the relationship between some autoantibodies including anti-β 2-glycoprotein Ⅰ (anti-β 2GPⅠ) and chronic liver disease. Methods A cohort of patients with chronic hepatitis B (CHB) and post-hepatitis B cirrhosis (PHBC) was studied for the serum anti-β 2GPⅠ levels by ELISA with purified β 2GPⅠ as antigen. The serum dsDNA, smooth muscle antibody (SMA) and ribonucleoprotein antibody (RNPA) were also detected. Results High positive rate was observed in patients with CHB or PHBC (20.9%, 9/43; 49.3%,35/75) comparing with that in control group (3.1%, 1/32) ( P < 0.01) and anti-β 2GPⅠ level in PHBC group was higher than that of CHB group ( P <0.05). High titer of autoantibodies was found in CHB and PHBC groups. The positive rate of anti-β 2GPⅠ was higher than those of dsDNA, SMA and RNPA (CHB: 4.6%, 11.6%,9.3%; PHBC: 8.0%, 22.6%, 14.6%). Conclusion HBV infection may contribute to the generation of autoantibody against β 2GPⅠ.

关 键 词：慢性肝病 β2糖蛋白Ⅰ 抗体 自身抗体 抗双链DNA抗体 

分 类 号：R512.62[医药卫生—内科学]