老年男性患者高密度脂蛋白胆固醇水平与疾病的关系  

The relationship between plasma high density lipoprotein-cholesterol and some diseases in elderly male patients

作　　者：毛利民[1] 褚徳发 陈曼丽[1] 侯鲁维[1] 钱贻简[1] 

机构地区：[1]卫生部北京医院内科,100730 [2]卫生部北京医院信息处,100730

出　　处：《中华老年医学杂志》2003年第10期584-586,共3页Chinese Journal of Geriatrics

摘　　要：目的　探讨不同水平的高密度脂蛋白胆固醇 (HDL C)与老年男性患者心肌梗死、原发性高血压、糖尿病、脑血管疾病、慢性肾功能衰竭、恶性肿瘤及其他血脂指标的关系。　方法　 1986～1998年 188例老年男性患者全部经尸检明确诊断 ,根据 6～ 13年间 (平均 10 2年 )连续每年体格检查取得的各项血脂平均值和临床资料 ,分为HDL C≤ 1 0 3mmol/L、HDL C 1 0 4～ 1 5 3mmol/L、HDL C≥ 1 5 4mmol/L 3组。观察其对各种疾病的影响。　结果　心肌梗死、糖尿病、肥胖和高甘油三酯血症的发生与HDL C水平降低明显有关 (P <0 0 1)。随着HDL C水平的升高 ,总胆固醇也随之增高 ,而甘油三酯、体重指数和总胆固醇 /HDL C比值均明显下降 (P <0 0 1)。总胆固醇随着年龄的增长有下降趋势。　结论　HDL C水平降低可能促进冠状动脉粥样硬化的发生和发展 ,使心肌梗死的患病率明显增高。老年人低HDL C水平不仅是心血管疾病的危险因素 。Objective To probe the relationship between serum high density lipoprotein -cholesterol (HDL-C) with various diseases in elderly male patients such as myocardial infarction, primary hypertension, diabetes mellitus, cerebrovascular disease, chronic renal failure and malignant tumor, etc. The relationship between HDL-C and other lipids or lipoproteins was also studied. Methods One hundred and eighty-eight elderly patients with complete clinical data including lipid profile studied annually from 1986 to 1998 and autopsy performed were divided into 3 groups according to their HDL-C level: HDL-C ≤1.03 mmol/L (first group), HDL-C 1.04-1.53 mmol/L (second group) and HDL-C ≥1.54 mmmol/L (third group). The influences of HDL-C in some diseases were observed. Results The suffering of myocardial infarction, diabetes mellitus, obesity and hypertriglyceridemia were obviously correlated with the reduced levels of HDL-C. With the increasing of HDL-C, serum total cholesterol(TC) also increased obviously , but triglyceride, body mass index and TC / HDL-C decreased obviously(P<0.01). It showed that the TC may decreased with the increases of age. Conclusions As reduced level of HDL-C is correlated with the suffering of coronary artery diseases, its initiation and progress might be prevented and the onset of myocardial infarction be decreased by adjusting HDL-C levels. Low level of HDL-C was not only one of the risk factors of cardiovascular disease but also indicator for some other chronic diseases .

关 键 词：老年男性患者 高密度脂蛋白 胆固醇 心肌梗死 糖尿病 高血压 

分 类 号：R592[医药卫生—老年医学]