低分子肝素钙在老年急性冠脉综合征(非ST段抬高)7年应用分析  

The Low Molecular Weight Heparin Calcium Treated the Acute Coronary Syndrome in Old Patients for Seven Years

作　　者：刘丰[1] 黄卫民[1] 张韶冈[1] 吴新达[1] 吴剑芸[1] 刑植斐[1] 

机构地区：[1]广州市第一人民医院老年病科,广州510180

出　　处：《中国医药导刊》2003年第5期345-346,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:回顾7年来低分子肝素钙在老年人急性非ST段抬高冠脉综合征的应用效果及安全性.方法:7年中339人65岁以上老年急性冠脉综合征,应用低分子肝素钙0.4～0.6ml,每日2次皮下注射连续治疗5～7天.观察临床事件:半年内急性ST段抬高性心肌梗死,心源性死亡、急性冠脉血管重建,出血情况和依从效果;并以年龄、血压、血色素及糖化血红蛋白对照分析.结果:不稳定性心绞痛组心脏事件8例(2.5%)(心肌梗死3例、急性冠脉重建2例、死亡3例),无严重出血,皮下出血3例(0.96%).对比分析心脏事件和出血情况在年龄(＞和＜75岁)血压(＞和＜140/90mmHg)血色素(＞和＜11克)糖化血红蛋白(＞和＜6.5%)的比较中差异不显著.患者依从性好.结论:低分子肝素钙对老年非ST段抬高的急性冠脉综合征治疗安全、有效.Objective: To reviewed the therapeutic effect and security of the low molecular weight heparin (LMWH) in a-cute coronary syndrome in old patients for 7 years. Methods: In 339 patients beloved 65 years who get the acute coronary syndrome (mi ST segment elevation),was received LMWH 0.4~ 0.6ml twice daily subeutaneously for5~7 days. The primary end points were acute myocardial infarction ( ST segment elevation ), cardiac death and urgent revascularization after treatment within half year, the hemorrhage within one month, and comparison of the age ( > or < 75year), hypertension( > or < 140\ 90mmHg), hemoprotein (>or<11g), Hbg1( > or < 6.5%). Results: During 7 years, the primary cardial events was 8 (2.5%) . The bleeding was 3(0.96%) . Compared in age, blood pressure, hemoprotein, hbg1, the difference was not significantly. Condition: LMWH calcium is effective and safe in old patients with acute coronary syndrome (no ST segment elevation).

关 键 词：老年 急性冠状动脉综合征 低分子肝素钙 药物治疗 

分 类 号：R541.4[医药卫生—心血管疾病]