增高的血清白介素-10反映肾小球疾病的增生程度  

The relationship of characteristic changes in glomerular diseases with the level of IL-10

作　　者：孙章松 

机构地区：[1]浙江省诸暨市人民医院肾脏内科,311800

出　　处：《浙江临床医学》2003年第10期732-733,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 比较肾小球疾病形态学改变和血清IL -10水平的关系。方法 ELISA法检测IL-10水平 ,光镜及免疫荧光明确病理类型。根据病理类型分为免疫复合物介导型 (IC)和非免疫复合物介导型 (NIC)、增生型和非增生型 ,用T检验比较它们的差异。结果 肾小球疾病血清IL-10较正常人增高 ,在增生型较非增生型增高 ,在IC型和NIC型之间无显著性差异。结论 肾小球疾病和体液免疫有关 。Objective To investigate the relationship of characteristic changes in glomerular diseases with the level of IL-10. Methods IL-10 protein was detected by ELISA, and normal pathological section and immunopathology were performed. According to pathologic diagnosis, the 23 cases were divided into 4 categories: proliferative, non-proliferative, immune complex (IC) mediated and non-IC-mediated. There differences were compared using student Ttest. Results The level of the IL-10 in patients with GD was higher than normal, no significant difference was noted between the serum of the IC and that of NIC; but was significantly higher in patients with proliferative diseases than that in patients with non-proliferative diseases. Conclusion the mechanism of GD is related with B cell-mediated immunity, and increased serum level of IL-10 reflects the proliferation of glomerular diseases.

关 键 词：肾小球疾病 白细胞介素-10 酶联免疫吸附实验 形态学改变 

分 类 号：R692.6[医药卫生—泌尿科学]