施他宁和善宁对门静脉高压症患者门静脉压力的影响  

Effects of somatostatin and octreotide on portal pressure in portal hypertensive patients undergoing TIPS procedure

作　　者：杨建芬[1] 吴性江[1] 曹建民[1] 韩建明[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院普通外科研究所,210002

出　　处：《中华普通外科杂志》2003年第10期620-621,共2页Chinese Journal of General Surgery

摘　　要：目的　研究生长抑素 (施他宁 )及其类似物 (善宁 )对门静脉高压症患者门静脉压力的影响。方法　 12例门静脉高压症经颈内静脉肝内门体分流术 (TIPS)后患者经颈内静脉留置于门静脉内支架下方的导管 ,分为两组 ,交替分别于TIPS术后 2 4h经静脉输入施他宁 (6mg/2 4h)或者善宁(0 6mg/2 4h)。对患者用药前、用药过程中门静脉压力连续监测。 结果　施他宁用药前后门静脉压力最大差值为 (9 4± 1 0 )cmH2 O ,善宁为 (5 0± 1 0 )cmH2 O(P <0 0 1)。施他宁用药后 1h门静脉压力显著下降并持续至用药后 36h(P <0 0 5 ) ,用药后 8、12、2 4h门静脉压力下降最明显 ;善宁用药1h后门静脉压力也有显著下降 (P <0 0 5 ) ,但用药 2 4h后门静脉压力即恢复至用药前水平 (P >0 0 5 )。结论　给予施他宁、善宁后均能显著地降低门静脉压力 ,给药后 8～ 12h作用最强 ,施他宁(6mg/2 4h)降低门静脉压力的作用较善宁 (0 6mg/2 4h)Objectives The purpose of this study was to compare the effect of somatostatin and octreotide on portal vein pressure in portal hypertensive patients.KG*2MethodsWT5”BZ Portal pressure in 12 patients with portal hypertension after TIPS was measured directly by means of a cathater placed in portal vein after infusion of somatostatin (6 mg/24h) or octreotide(0 6 mg/h). The drugs was infused intravenously and alternatively in each individual patient on day 1 or day 3 after TIPS. Portal pressure was assessed at baseline and at 1、2、4、6、8、12、24、30、36 hours after infusion of each drug.KG*2ResultsKG1The average decrease of portal pressure was 9 4±1 0 cm H 2 O and 5 0±1 0 cm H 2 O respectively after the intravenous infusion of somatostatin or octreotide( P <0 01). There was a significant reduction in portal pressure at 1、4、8 and 24 hours with the effect remained significant at 36 hrs after somatostatin infusion, while the effect was not statistically different in octreotide group.KG*2ConclusionsWT5”BZ Both somatostatin and octreotide decrease portal pressure significantly, but the effect of somatostatin was more significant than that of octreotide. The maximum decrease in portal pressure was detected at 8 h to 12 h after infusion of somatostatin and octreotide .

关 键 词：施他宁 善宁 门静脉高压症 门静脉压力 颈内静脉肝内门体分流术 

分 类 号：R657.3[医药卫生—外科学]