心房钠尿肽对血管紧张素Ⅱ促血管平滑肌细胞增殖和c-fos原癌基因表达的影响  

EFFECT OF ANP ON ANGIOTENSIN I-STIMULATED MULTIPLICATION AND C-FOS ONCOGENE EXPRESSION OF SHR VASCULAR SMOOTH MUSCLE CELLS

作　　者：吴建明[1] 孙双丹 廖永伯 唐朝枢[1] 

机构地区：[1]北京医科大学心肺内分泌研究室,北京100083 [2]中国医学科学院心血管病研究所

出　　处：《生理学报》1992年第2期181-185,共5页Acta Physiologica Sinica

摘　　要：本工作应用细胞培养、~3氢·胸腺嘧啶核苷参入和斑点杂交的方法,观察到血管紧张素Ⅱ(AGTⅡ)明显促进培养的自发性高血压大鼠的主动脉平滑肌细胞(VSMC)的增殖和c-fos原癌基因的表达;该效应可显著为心房钠尿肽(ANP)所抑制。By means of technique of cell culture, ~3H-thymidine incorporation and dotblot, it was demonstrated that angiotensin Ⅱ(AGT Ⅱ) stimulated proliferationand c-fos oncogene expression in cultured SHR vascular smooth muscle cells (VSMC)in a dose-dependent manner. This effect of AGT Ⅱ was significantly inhibited byco-incubation with ANP. The results suggest that proliferation of VSMC is regulat-ed by some interaction between AGT Ⅱ and ANP.

关 键 词：心房钠尿肽 血管紧张素II 原癌基因 

分 类 号：R335[医药卫生—人体生理学]