脑室注射6-羟多巴胺对黄鼠冬眠入眠的影响  

EFFECT OF INTRAVENTRICULAR INJECTION OF 6-HYDROXYDOPAMINE ON THE INITIATION OF HIBERNATION IN GROUND SQUIRRELS

作　　者：蔡益鹏[1] 黄钦恒 赵海青[1] 张崇理[2] 王红[2] 

机构地区：[1]北京大学生物系,北京100871 [2]中国科学院动物研究所,北京100080

出　　处：《生理学报》1992年第2期175-180,共6页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：采用脑室内注射化学去交感药物6-羟多巴胺(6-OHDA)的方法,观察了人为地降低脑内去甲肾上腺素(NE)系统活动对达乌尔黄鼠入眠的影响。结果表明:脑室注射100-200μg6-OHDA使脑内NE含量减少50％以上,明显促进黄鼠入眠,平均入眠诱导期比自然冬眠动物明显缩短,整个冬眠季内冬眠时间延长,冬眠黄鼠仍具有正常的入眠觉醒周期。这些结果提示脑内NE系统活动水平降低是触发动物入眠的重要因素之一。The effect of forced depletion of brain norepinephrine (NE) on the onset ofhibernation was observed in the ground squirrel (Citellus dauricus) by intraventricularinjection of 6-hydroxydopamine (6-OHDA). The results showed: (1) Intraven-tricular injection of 100--200 μg 6-OHDA, which depletcd 50--60% NE, mark-edly facilitated the onset of hibernation, i.e. the average induction period for hiber-nation in the treated animals was significantly shorter than that of the natural hibernating animals. (2) The average total torpor time in the treated animals waslonger than that of natural hibernating animals. (3) All hibernating animalstreated with 6-OHDA were able to wake up from deep hibernation spontaneouslyand undergo normal hibernation bouts. The results indicate the decrease of NEsystem activity in brain is one important factor in triggering the onset of hiberna-tion.

关 键 词：科眠 去甲肾上腺素 血清素 

分 类 号：R338.63[医药卫生—人体生理学]