头端延髓腹外侧区注射5-羟色胺对应激性高血粘度及血压升高的影响  

MICROINJECTION OF 5-HT INTO THE ROSTRAL VENTROLATERAL MEDULLA REDUCED THE HYPERVISCOSITY AND ELEVATION OF BLOOD PRESSURE INDUCED BY STRESS

作　　者：翁可 郭学勤[2] 梁子钧[3] 

机构地区：[1]温州医学院生理教研室 [2]上海医科大学生理学教研室,上海200032 [3]上海医科大学生物物理学教研室,上海200032

出　　处：《生理学报》1992年第3期244-253,共10页Acta Physiologica Sinica

基　　金：国家自然科学资金资助(No.3880909);国家教育委员会博士点资金资助(No.89-36)

摘　　要：实验用Wistar大鼠62只,采用束缚加悬吊的方法引起应激性高血粘度和血压升高。结果观察到,清醒大鼠束缚加悬吊二天可引起应激性高血粘度和血压升高。第四脑室内注射5-羟色胺(5-HT25μg/10μl)或在双侧延髓腹外侧区头端(rVLM)微量注射5-HT(4μg/0.5μl/每侧)均可抑制应激性高血粘度和血压升高,若预先在双侧rVLM微量注射5-HT受体阻断剂肉桂硫胺(4μg/0.5μl/每侧)后再在第四脑室或延髓腹外侧区内注入上述同剂量的5-MT,则5-HT降低应激性高血粘度和血压升高的作用消失。看来上述5-HT的作用是通过rVLM内5-HT受体的激活来实现的。Experiments were carried out on 62 wistar rats. The hyperviscosity andelevation of blood pressure were induced by hanging and restraining the ratswith their four limbs tied on a frame. It was found that microinjection of 5-HT(25μg/10μl) into the 4th ventricle of the brain or bilateral microinjection of5-HT (4μg/0.5μl/site) into rostral ventrolateral medulla (rVLM) reduced st-ress-induced hyperviscosity (p<0.01) and elevation of b1ood pressure (p<0.01).The effect of 5-HT injected into the 4th ventricle or rVLM was blocked by bi-lateral microinjection of cinanserine (4μg/0.5μl/site) into rVLM. These resultssuggest that microinjection of 5-HT into 4th ventricle and rVLM could reducestress-isduced hyperviscosity and elevation of blood pressure and these effects wereprobably mediated via 5-HT receptors in the rVLM.

关 键 词：应激 血粘度 血清素 血压 

分 类 号：R331[医药卫生—人体生理学]