产超广谱β-内酰胺酶细菌感染相关因素分析  

Related Factor Analysis of Extended-spectrum β-Lactamases-producing Bacteria Infection

作　　者：王豫平[1] 王慕云[1] 廖致红[1] 

机构地区：[1]广西医科大学第五附属医院,广西柳州545001

出　　处：《中华医院感染学杂志》2003年第10期972-974,共3页Chinese Journal of Nosocomiology

摘　　要：目的　了解产超广谱 β 内酰胺酶 (ESBLs)细菌感染患者对抗菌药物耐药性、治疗及预后情况。方法　对2 0 0 2年 1～ 12月经标本送检证实为产ESBLs细菌感染的病历进行回顾性调查。结果　 4 5例产ESBLs细菌感染患者中大肠埃希菌 30例、肺炎克雷伯菌 15例 ,与非产ESBLs菌比较耐药性明显增高 ,有 39例合并有 1～ 4项基础疾病 ,死亡率 2 2 2 2 % ,抗菌药物应用中不按药敏结果使用的高达 5 3 33%。结论　ESBLs细菌感染者耐药性明显增高 ,往往合并有多项基础疾病 ,强化医师对ESBLs的认识 。OBJECTIVE To investigate the resistance to antibiotic treatment, prognosis and accompanied of the patients infected by extended-spectrum β-lactamases (ESBLs)-producing bacteria. METHODS The cases infected by ESBLs bacteria from Jan 2002 to Dec 2002 in our hospital were retrospectively studied. RESULTS Thirty cases were infected by Escherichia coli, 15 cases by Klebsiella pneumoniae in all the 45 cases of ESBLs bacteria infection. Compared with other bacteria, the resistance to antibiotic of the patients caused by ESBLs bacteria is remarkable higher. The mortality was 22.22%. Thirty nine cases concomitantly complicated by 1-4 other kinds of diseases. There were up to 53.33% patients prescribed antibiotic not according to the drug sensitive test. CONCLUSIONS The patients infected by ESBLs bacteria are often concomitant with multiple other diseases. It is essential for doctors to intensify the understanding of ESBLs, and use the antibiotic rationally.

关 键 词：超广谱Β-内酰胺酶细菌 感染 

分 类 号：R378.2[医药卫生—病原生物学]