高胆固醇血症病人的红细胞膜ATP酶活性变化  

ERYTHROCYTE MEMBRANE ATPases ACTIVITIES IN HYPERCHOLESTEROLEMIA PATIENTS

作　　者：杨绍忞 陈毓华[1] 张晓先 

机构地区：[1]南京医学院病理生理学教研室,南京210029

出　　处：《生物化学与生物物理进展》1992年第1期47-49,共3页Progress In Biochemistry and Biophysics

摘　　要：研究表明高胆固醇血症病人的红细胞膜Na^+-K^+-ATP酶和ca^(2+)-Mg^(2+)-ATP酶活性均降低,并且血浆总胆固醇和低密度脂蛋白-胆固醇浓度与这两种酶活性呈高度负相关,而血浆高密度脂蛋白-胆固醇浓度与Na^+-K^+-ATP酶活性呈正相关。这些变化的研究,对于进一步探讨动脉粥样硬化的发生机制及其防治可能具有重要意义。In order to study effect of plasma lipids on ATPases activities in erythrocyte membrane, contents of plasma TC, LDL-C and HDL-C and activities of Na^+-K^+- and Ca^(2+)-Mg^(2+)-ATPase were determined in 28 hypercholesterolemia patients and 16 control.The Na^+-K^+- and Ca^(2+)-Mg^(2+)-ATPase activities were reduced in these patients. Negative correlations were shown between two ATPase activities and plasma TC and LDL-C levels, but positive correlation was shown between Na^+-K^+-ATPase activity and plasma HDL-C level in all groups. These studies may be important for probing into mechanism of atherosclerosis formation and prevention and cure of this disease. This problem is discussed in the paper.

关 键 词：高胆固醇血症 红细胞膜 ATP酶 

分 类 号：R559.02[医药卫生—血液循环系统疾病]