葡萄糖衍生物的合成及其模拟SOD的活性研究  

Studies on Synthesis of Glucose Derivatives and Their Activities for Simulating SOD

作　　者：黄红卫[1,2] 熊继敏 岳保珍 鲁纯素[1,2] 

机构地区：[1]北京医科大学药学院 [2]北京医科大学物化教研室,北京100083

出　　处：《生物化学杂志》1992年第3期283-287,共5页

基　　金：国家自然科学基金

摘　　要：合成含有组氨酸的葡萄糖衍生物,其结构经IR、~1H-NMR及^(13)C-NMR分析得以确证,同时还测定了它们的超氧化物歧化酶(SOD)样活性。实验结果表明该衍生物与铜离子形成螯合物后,对超氧负离子自由基有清除作用(但远弱于天然SOD),并且对红细胞膜脂质过氧化有抑制功效。The glucose derivatives with SOD-like activities have been synthesized.Their structures were identified by NMR, UV, IR etc., and the SOD-like activities of Cu(*****II)-chelate complexes of glucose derivatives were investigated by the Cytochrome C reduction method.Their bio-activities of antilipid peroxidation have been measured by MDA-TBA test.The compounds were found to have effective inhibition of lipid peroxidation of erythrocyte membrane.

关 键 词：葡萄糖衍生物 超氧物歧化酶 

分 类 号：Q532.3[生物学—生物化学]