傅立叶变换红外光谱(FT-IR)用于血糖无损检测的研究  

Study A on noninvasive measurement of blood glucose with FT-IR ATR technique.

作　　者：孙颖[1] 傅贤波[2] 周勇[1] 杨展澜[1] 杨丽敏[1] 张利[1] 周孝思[2] 徐怡庄[1] 凌晓峰[2] 沈韬[2] 翁诗甫[1] 吴瑾光[1] 

机构地区：[1]北京大学化学与分子工程学院,北京100871 [2]北京大学第三医院,北京100083

出　　处：《中国微创外科杂志》2001年第3期159-161,共3页Chinese Journal of Minimally Invasive Surgery

基　　金：国家自然科学基金项目( 39730 16 0 );国家重点基础研究发展规划项目(G19980 6 1311)资助

摘　　要：目的　血糖无损检测的可行性研究。　方法　傅立叶变换红外光谱测受试者中指的红外光谱 ,将 112 3cm-1附近的葡萄糖特征峰的相对强度与快速血糖仪所测血糖值进行比较。　结果　112 3cm-1附近的特征峰相对强度的变化与血糖值的变化基本同步 ,该峰的相对强度与血糖值明显相关(R =0 83485 ,SD =0 135 6 6 ,P <0 0 0 0 1) ,峰的相对强度可以反映人体血糖值的变化 ,的确能作为人血糖值的一个数量指标。　结论　FT -IRATR法进行人体血糖的无创性测定和监测是可行的。Objective To study a noninvasive determination of blood glucose concentration in human body. Methods Using FT-IR AIR technique, the relative intensity of～1123cm 1 bands was compared with the determinating results of blood glucose with a instant blood glucose instrument. Results The relative intensity change of ～1123cm 1 bands in mid-infrared spectra of middle finger, was in accordance with the variation of blood glucose concentration in human body, and its relative intensity was significantly related to the blood glucose concentration in human body.(R=0.83485. SD=0.13566.P<0.0001) Conclusions This method provides a way to develop a noninvasive and convenient measurement of blood glucose for clinical diagnoses.

关 键 词：傅立叶变换红外光谱 血糖 无创检测 糖尿病 围手术期 

分 类 号：R446.112[医药卫生—诊断学]