赤爱胜蚯蚓(Eisenia Foetida Sarigny)纤溶酶的研究Ⅱ药理学作用  

Study on Earthworm Fibiindysin of Eisenia Foetida Sarigny II Pharmacology Action

作　　者：杨志兴[1] 杨学成[1] 张云湖[1] 马元生 李洪超[1] 刘伟民[1] 赵晓祥[1] 姜凯波[1] 张昕[1] 赵克强 董桂华 张凤琴 

机构地区：[1]黑龙江省科学院应用微生物研究所 [2]哈尔滨市卫健制药厂

出　　处：《生物技术》1992年第1期15-18,共4页Biotechnology

摘　　要：对蚯蚓纤溶酶进行了哈白兔体内、体外溶栓、抗凝试验,分别以蛇毒抗栓酶和尿激酶不同剂量组作对照试验,均有显著的溶解血栓功能.另外,蚯蚓纤溶酶溶解天然血块,对纤维蛋白原含量及凝血时间影响的药理学试验,结果证明蚯蚓纤溶酶具有溶栓与抗凝作用.In vitro and in vivo thrombus-dissloving, anti-Coagulation assay of earthworm fibrinolysin are carried out on rabbit, using various doses of ancrod and urokinase as control, the results show that all these three have sihnificent thrombus-dissloving function. Besides, pharmaceutical assay are also performed on dissloving natural thormbus, fibrinogen content, and coagulating time, thus demonstrate earthworm fibrinolysin has the functions of thrombus-dissloving and anti-coagulation.

关 键 词：蚯蚓纤溶酶 溶血栓 药理 

分 类 号：R977.3[医药卫生—药品]