单眼剥夺对金黄地鼠视觉中枢GABA神经元分布的影响  

EFFECTS OF MONOCULAR DEPRIVATION ON THE DISTRIBUTION AND NUMBER OF GABA-IMMUNOPOSITIVE NEURONS IN THE VISUAL CENTRE OF THE HAMSTER

作　　者：吴奇久[1] 李俊凤[1] 韩戬 孙俊世 

机构地区：[1]中国科学院生物物理研究所视觉信息加工开放研究实验室,北京100101

出　　处：《生物物理学报》1992年第4期569-574,共6页Acta Biophysica Sinica

基　　金：中国科学院重大项目"视觉信息加工"子课题

摘　　要：用免疫细胞化学技术观察了单眼剥夺后金黄地鼠视觉中枢GABA神经元分布的变化。结果表明:单眼剥夺后,金黄地鼠视皮层和上丘的GABA阳性神经元暂时性增多,但剥夺后六个月,其数目显著减少。在单眼剥夺前和剥夺后侧膝体中GABA阳性神经元数目没有明显差异。剥夺眼对侧视皮层GABA阳性神经元数比剥夺眼同侧视皮层GABA神经元数目少。单眼剥夺后视觉中枢GABA神经元类型及形态与剥夺前没有差别。晚期单眼剥夺也能引起视觉中枢GABA神经元数量和分布的变化。以上结果表明,单眼剥夺后视觉中枢抑制神经元的结构发生了变化。Physiological studies suggest that monocular deprivation results in an extensive reduction of the capability of the deprivation eye to activate visual cortical cells. The nature of the change taking place in the cortex is a subject of controversy. One line of evidence favours a redistribution of the excitatory terminals. The another suggests that the deprivation eye input is in some way suppressed, possibly by GABA-mediated intracortical inhidition. Morphological studies obtained contradictory results too on the controversy mentioned above.The present study indicated a marked change in the number and distribution of GABA-immunopOsi tive neurons in the visual centres of hamster after monocular deprivation. This change is displayed mainly in the visual cortex. It supports the viewpoint of redistribution.

关 键 词：单眼剥夺 视觉中枢 生物信息论 

分 类 号：Q811.4[生物学—生物工程]