药物对高原人体运动时心率的影响  

Effect of Some Medicine on Heart Rate at High Altitude

作　　者：王伟[1] 哈振德[1] 张芳[1] 张西洲[1] 崔建华[1] 马勇[1] 

机构地区：[1]解放军第18医院,新疆叶城844900

出　　处：《临床军医杂志》2003年第4期5-7,共3页Clinical Journal of Medical Officers

基　　金：兰州军区科研基金(LXH01-06)

摘　　要：目的 探讨在高原低氧条件下药物对人体运动心率(HR)的影响。方法 对进驻海拔4 100 m20 d的50名健康青年随机分为服用复方红景天组、西氏胶囊组、乙酰唑胺组、吸入一氧化氮(NO)组和对照组,每组10人。在服(吸入)6 d前后的安静时、踏阶运动5min及恢复5 min时分别检测HR。结果 服药前运动5 min及恢复5 min时5组HR较安静时增高非常明显(P<0.01);服药后安静时较服药前安静时HR4组服药组降低非常显著(P<0.01);服药后运动5 min时较服药前运动5 min时HR4组服药组降低显著(P<0.05);服药后恢复5min较服药前恢复5min HR西氏胶囊组及乙酰唑胺组降低显著(P<0.05),红景天组及NO组降低非常显著(P<0.01);服药后安静时HR4组服药组较对照组降低显著(P<0.05)服药后恢复5 min时HR红景天组及NO组较对照组降低显著(P<0.05)。结论 服用红景天、西氏胶囊、乙酰唑胺及吸入NO均能有效地提高和改善低氧条件下人体运动耐力和降低HR;吸入NO和服用红景天效果更明显。Objective To study the effect of some medicine on the heart rate (HR) after exercise athigh altiude. Methods 50 youths, exposed to alitude of 4100m for 20 days, were divided randomly into rholida,Xi' s capsule, acetazolamide, nitric oxide (NO) and conrol group, each 10 in a group, and their HR were observed before and after the step-stair-exercisee for 5 min, and the recovered HR at 5 min. To repeat the test after taking medicine or inhaling NO( 10ppm,30 min per day)for 6 days. Results Afyer taking medicine or inhaling NO for 6 days, the resting HR, exercising HR and recovering HR were lower( P < 0.01 or P < 0.05) , and compared with control group,there are notable discrepancy (P <0.05). Conclusion Taking acetazolamide,Xis capsule and, above all,rholida or inhaling NO could improve the HR at high altitude.

关 键 词：高原 运动 药物 心率 复方红景天 西氏胶囊 乙酰唑胺 一氧化氮 

分 类 号：R339.54[医药卫生—人体生理学]