血清FE_3和HPL联合测定胎儿胎盘功能  

Combined Measurement of Maternal Serum FE_3 and HPL for Determination of Fetus-Placenta Function

作　　者：彭杨水[1] 李格芳[1] 夏定纹[1] 

机构地区：[1]中山大学附属第一医院胎儿医学中心,510080

出　　处：《放射免疫学杂志》2003年第5期275-277,共3页Journal of Radioimmanology

摘　　要：目的 :探讨血清游离雌三醇 (FE3 )和 (HPL)联合测定胎儿 -胎盘单位功能的应用。方法 :FE3和HPL均采用放射免疫分析 (RIA)测定。结果 :妊娠合并高血压综合征 ,胎儿宫内窘迫和妊娠 33周以上合并糖尿病及 3级胎盘孕妇FE3 含量均比正常对照组低 (p <0 0 5 ) ;胎儿宫内发育迟缓 2 9周后 ,妊娠合并高血压综合征和 3级胎盘孕妇HPL含量均比对照组低 (p <0 0 5 ) ;单项测定阳性率低 ,联合测定 ,胎儿宫内发育迟缓阳性率达 85 7% ,妊娠合并糖尿病阳性率达 5 0 0 % ,3级胎盘阳性率达 5 7 7%。结论 :FE3 和HPL联合测定能判断胎儿Objective To investigate the clinical application of combined measurement of maternal serum FE 3 and HPL for determination of fetus-placenta function. Methods Maternal serum FE 3 and HPL levels were measured with RIA in 86 complicated and 39 non-complicated pregnant women. Results Serum FE 3 contents in pregnant women complicated with hypertensive syndrome, intrauterine fetal distress, gestation above 33 wks complicated with diabetes and 3rd grade placenta were significantly lower than those in non-complicated ones ( p <0 05). Serum HPL contents in pregnant women complicated with intrauterine fetal retardation above 29 wks, hypertensive syndrome and 3rd grade placenta were also significantly lower than those in non-complicated controls ( p <0 05). Measurement of either single item yielded rather low positive rate. With combined measurement, positive rate in intrauterine fetal retardation was 85 7%, 50% in those complicated with diabeetes and 57 7% in those with 3rd grade placenta. Conclusion Combined measurement of materral serum FE 3 and HPL could improve the early diagnosis of high-risk pregnancies.

关 键 词：雌三醇 胎盘催乳素 胎儿-胎盘单位功能 放射免疫分析 高危妊娠 

分 类 号：R714.5[医药卫生—妇产科学] R714.2[医药卫生—临床医学]