甲亢患者血清TGA、TMA与TRAb联检的临床意义  

Clinical Significance of Combined Determination of Serum TGA, TMA and TRAb in Patients with Hyperthyroidism

作　　者：李新[1] 屈婉莹[1] 姚稚明[1] 赵洪山[1] 薛翠英[1] 

机构地区：[1]北京医院核医学科,100730

出　　处：《放射免疫学杂志》2003年第5期258-260,共3页Journal of Radioimmanology

摘　　要：目的 :对 84例甲亢患者的三种抗体进行联合测定 ,探讨在甲亢患者中三种抗体之间的关系及其对诊断自身免疫性甲状腺疾病的价值。方法 :84例甲亢患者按TGA、TMA浓度分为三组即TGA、TMA阴性组 (TGA、TMA <2 0 % )、阳性组 (TGA、TMA≥ 2 0 %～ <4 0 % )、强阳性组 (TGA、TMA≥ 4 0 % )。结果 :阳性率比较TRAb阳性患者占甲亢患者总人数的 71 5 % ,TRAb阳性率在阴性组占 4 2 9% ,阳性组占 75 0 % ,强阳性组占 85 7% ,三组甲亢患者及三组甲亢TRAb阳性患者血清TRAb测定结果的比较 :阳性组与阴性组比较均无显著性差异 ,强阳性组较阴性组与阳性组均明显增高。结论 :本组甲亢患者TRAb阳性率不仅与文献报告相符合 ,且显示TRAb的阳性率随着TGA、TMA阳性率的提高有增加趋势。 84例甲亢患者中TGA、TMA强阳性占 4 1 7% 。Objective To explore the interrelationship among the three thyroid antibodies and their role in clinical diagnosis of thyroid auto-immune diseases by combined determination of serum TGA, TMA and TRAb in 84 patients with Hyperthyroidism.Methods Based upon the serum concentrations of TGA and TMA, the 84 patients were divided into three groups: TGA, TMA negative group (TGA, TMA<20%,n=21), positive group (TGA,TMA≥20%～<40%, n=28) and strongly positive group (TGA, TMA≥40%, n=35). Serum TRAb cancentrations were measured in all these patients. Results Serum TRAb concentrations were positive (TRAb>6 84u/L) in 60 of the 84 patients with byperthyroidism (71 5%). For the separate groups, TRAb concentrations were positive in 42 9% of the patients of the TGA, TMA negative group, 75 0% of the TGA, TMA positive group and 85 7% of the strongly positive group. TRAb concentrations were significantly higher in patients of the strongly positive group than those in patients of the positive and negative group, but were not much different between patients of the positive and negative group. Conclusion Posivive rate of the serum TRAb increased along with the increase of positive rate of TGA and TMA. In this series of 84 thyrotoxic patients, TGA and TMA concentrations were strongly positive in 41 7% of them. It was possible that some of those strongly postive patients were of the Hashimoto type instead of Graves type.

关 键 词：促甲状腺素受体抗体 格雷氏病 桥本氏病 临床意义 血清学检测 TGA MA TRAB 甲状腺功能亢进症 

分 类 号：R581.1[医药卫生—内分泌]