丹参对肺水肿大鼠白细胞介素-8和内皮素的影响  

Effect of Multiorrhizae on Change of Interleukin-8 and Endothelin in Rat Lung of Edema

作　　者：吴山[1] 盛延良[2] 蒋志学[2] 孙明[2] 

机构地区：[1]重庆医科大学附属第一医院,重庆410016 [2]佳木斯大学,黑龙江佳木斯154002

出　　处：《辽宁中医杂志》2003年第10期796-797,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的 :研究丹参对氯气染毒致大鼠肺水肿时白细胞介素 - 8和内皮素变化的影响。方法 :用氯气染毒致大鼠肺水肿 ,利用放免技术测定大鼠血中白细胞介素 - 8和内皮素浓度。结果 :肺水肿时白细胞介素 - 8和内皮素水平明显上升 ,应用丹参后均明显下降。结论 :丹参可降低白细胞介素 - 8和内皮素水平 ,从而减轻氯气对肺脏的损伤。Objective :We studied the effect of miltiorrhizae on the change of the concentrations of endothelin(ET-1)and interleukin-8(IL-8) in plasm of rat lung model of edema. Methods :The rat lung model of edema was prepared by being exposed to chlorine gas.Radioimmunoassay (RIA) were used to measure the concentrations of ET-1 and IL-8. Results :The plasma concentrations of ET-1 and IL-8 in rat exposed to chlorine gas were increased significantly in lung edema group,but that were decreased significantly in miltiorrhizae group. Conclusions :Miltiorrhizae can reduce the plasm concentrations of ET-1 and IL-8,miltiorrhizae possessed protective effects on lung edema.

关 键 词：丹参 白细胞介素-8 内皮素 肺水肿 大鼠 

分 类 号：R563[医药卫生—呼吸系统]