卡铂栓剂溶出度实验方法研究  

Dissolution test of carpolatine in suppository

作　　者：牛丽红[1] 陈启蒙[2] 

机构地区：[1]天津医科大学第三医院,天津300203 [2]天津医科大学药学院,天津300070

出　　处：《天津药学》2003年第5期4-6,共3页Tianjin Pharmacy

摘　　要：目的 :建立测定卡铂栓溶出度的实验方法 ,提供药品评价和质控的依据。方法 :溶出度的测定采用比色法 ,水平滚筒溶出装置 ,蒸馏水 ( p H 5～ 7)为溶出介质。结果 :卡铂栓剂溶出度 5小时为 6 5 %以上 ,6小时为 80 %以上。结论 :此方法准确、快速、简便。为控制卡铂栓的质量 。Object: To establish a method for determining the dissolution rates of carpolatine in suppository and provided a basis for drug appraisal and quality control. Methods: The dissolution rate was determined by colorimetry with the level roll dissolution instrument and water (pH 5-7) as dissolution medium. Results: The dissolution of carpolatine in suppository after 4 and 6 hours were 65% and 80%, respectively. Conclusion: The method is simple, rapid and accurate. It is necessary to determine the dissolution for quality control.

关 键 词：卡铂栓剂 溶出度 实验方法 药品评价 质量控制 

分 类 号：R927.11[医药卫生—药学] R944.23