半枝莲对宫颈癌细胞钙信号系统的影响  

Influence of Scutellaria barbata on Calcium Beaconage of Cervix Cancer Cells

作　　者：高冬[1] 高永琳[2] 白平[1] 

机构地区：[1]福建中医学院,福州350003 [2]福建医科大学,福州350004

出　　处：《中药材》2003年第10期730-733,共4页Journal of Chinese Medicinal Materials

基　　金：福建省卫生厅青年基金资助项目 (3 2 0 2 1980 2 1#)

摘　　要：为探讨半枝莲对Hela细胞胞内游离钙浓度的影响及其抗癌作用机理。利用荧光染料Fura 2在细胞内能与游离钙结合 ,在一定波长光的激发下可发出荧光的特性 ,根据荧光的强度来检测游离钙的变化 ,结果显示半枝莲对Hela细胞增殖的抑制作用不明显 ,但可通过促进细胞内储藏钙的释放和胞外钙离子的内流 。To study the influence of Scutellaria barbata D Don on cytoplasmatic free Ca 2+ concentration of cervix cancer cells and its mechanism on anti cancer. Fluorochrome Fura 2 could combine with free Ca 2+ and then give off fluorescent under the condition of stimulating by some wavelength light The changes of free Ca 2+ were tested according to the intensity of fluorescent The results showed that Scutellaria barbata D Don could stimulate the cytoplasmatic store calcium out flow and extracellular Ca 2+ inflow, and could obviously improve the concentration of cytoplasmatic free Ca 2+

关 键 词：半枝莲 宫颈癌 抗癌药 游离钙 HELA细胞 

分 类 号：R282.71[医药卫生—中药学] R273.933[医药卫生—中医学]