潘生丁与乙酰唑胺负荷脑血流灌注显像的对比研究  

A comparative study of dipyridamole and acetazolamide in stress cerebral perfusi on imaging

作　　者：马宏星[1] 陈绍亮[1] 许兰文[1] 许开平[1] 石洪成[1] 李蓓蕾[1] 

机构地区：[1]复旦大学附属中山医院核医学科

出　　处：《中华核医学杂志》2003年第5期276-278,T003,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨潘生丁负荷脑血流灌注显像的可行性。方法　 8例健康志愿者和 2 3例患者于 1周内先后进行静息、乙酰唑胺及潘生丁负荷脑血流灌注显像。自身比较静息 负荷状态下的脑血流灌注情况。结果　健康志愿者的脑血流灌注双侧对称。患者组中 8例正常 ;1例患者静息态脑局部血流灌注低下 ,潘生丁和乙酰唑胺负荷态正常 ;余 14例静息态局部脑血流灌注低下或正常 ,应用潘生丁 乙酰唑胺后局部脑血流量更低或出现低灌注区。两药显示低血流储备区的能力无明显差异。Objective To investigate the possibility of using dipyridamole instead of acetazola mide as a stress agent in stress cerebral perfusion imaging. Methods Eight healthy volunteers were taken as controls, 23 patients suspected as suff ering from ischemic cerebral vascular diseases were taken as patient group. All subjects underwent rest, acetazolamide and dipyridamole stress cerebral perfusio n imaging separately within one week. Visual evaluation and region of interest ( ROI) method was us ed to compare cerebral perfusion under rest and stress conditions. Results The cerebral perfusion of the normal control group was symmetric und er rest and stress conditions. For the patient group, 8 patients were classified with normal cerebral blood flow (CBF). The CBF of the remaining patients were normal or ischemic under rest conditon. Under stress condition, the blood flow became e ven lower, or new ischemic areas occurred. The effects of dipyridamole and aceta zolamide were similar to each other in 5 patients. The effect of dipyridamole wa s stronger in 5 patients. The effect of acetazolamide was stronger in 4 patients . In general, the effects of the two drugs in showing the area with low flow res erve were much alike. Conclusion Dipyridamole can be used as a stress agent in cerebral perfusion imaging, taking the place of acetazolamide.

关 键 词：潘生丁 乙酰唑胺 负荷脑血流灌注显像 脑血流储备功能 脑血管扩张作用 

分 类 号：R817.4[医药卫生—影像医学与核医学]