海洛因依赖者心理渴求的SPECT脑显像研究  

The SPECT study on the regional cerebral blood flow of heroin addicts during cue-induced heroin craving

作　　者：王政清[1] 赵阁元 刘青龙[1] 王玉华[1] 王金敏[1] 王烁[1] 

机构地区：[1]唐山市中医院核医学科,063000 [2]唐山市医疗保险基金管理中心

出　　处：《中华核医学杂志》2003年第5期279-280,T003,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的　研究与海洛因相关的环境诱导急性脱毒后海洛因依赖患者心理渴求的局部脑血流 (rCBF)灌注变化特征。方法　选择脱毒治疗 1个月后海洛因依赖患者 2 5例 ,给予与海洛因相关的环境线索刺激 (暴露 ) 15min导致其心理渴求 ,采用SPECT仪检测rCBF的变化。结果　海洛因环境刺激明显增加额叶、颞叶皮层及杏仁核区等脑区的rCBF ,而其他脑区如顶叶、枕叶、扣带回及基底节等区域的脑血流灌注则无明显变化。结论　海洛因相关环境可诱导患者对药物的心理渴求 ,是患者脱毒后发生复吸的最主要因素之一 ;额叶。Objective To explore the character of the regional cerebral blood flow (rCBF) of heroin a ddicts during the exposure to the heroin-related cues. Methods Twenty-five heroin dependent individuals undergoing detoxification for more th an one month were enrolled in the present study. All subjects were exposed to th e heroin-related cues for 15 min. The rCBF was measure d in these patients before and after exposure to heroin-related cues. Re sult The rCBF in the frontal, temporal cortex and amygdala was signific antly increased during the exposure to heroin-related cues. Conclusion The findings indicate that drug-related cues play a critical role in the r elapse of drug dependence; and the frontal, temporal cortex and amygdala are inv olved in the relapsing process.

关 键 词：海洛因依赖 心理渴求 SPECT脑显像 局部脑血流灌注 吸毒 

分 类 号：R817.4[医药卫生—影像医学与核医学]